alexa Adiponectin Regulation Of AMPK On Oleanolic Acid Treated Sprague Dawley Rats
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Conference on Diabetes and Diabetic Nursing Care
September 20-21, 2017 Charlotte, USA

Emmanuel Mukwevho, Matumba M G and Nyakudya T T
North West University, South Africa
Posters & Accepted Abstracts: J Diabetes Metab
DOI: 10.4172/2155-6156-C1-070
Abstract
AMPK is known to control both glucose and lipid metabolism, two main candidates critical in the development of type-2 diabetes (T2D). Studies have shown that AMPK can be activated by adiponectin. Patients suffering from T2D are known to have low adiponectin concentration in their blood plasma. In this study, we have assessed one of the anti-diabetic compound Oleanolic acid (OA) if it could produce desirable effect in upregulating adiponectin concentration and the subsequent regulation of AMPK. Sprague Dawley rats were fed with high fructose diet (HFD) to induce T2D, and the rats that developed insulin resistance were considered as diseased, they were then treated with OA. Analysis of adiponectin concentration in blood plasma was done, AMPK gene expression and subsequent genes that play vital role in glucose and lipid metabolism (GLUT-4 and CPT-1) in skeletal muscle tissue was also performed. The results showed 1.19-fold increase in blood plasma adiponectin concentration after OA administration. Furthermore AMPK gene expression showed 3.98-fold increase and GLUT-4 gene expression was increased with 1.5-fold whereas CTP-1 gene expression was increased with 1.59-fold. These results clearly indicate that OA produced good effects in ameliorating insulin resistance since it could upregulate all the genes and adiponectin concentration which are well known to be abnormally suppressed in a situation of T2D. In conclusion, these studies further confirm that OA can be used as an effective therapeutic agent to ameliorate T2D and these studies also suggest that OA’s mechanism of action it could be through AMPK pathway.
Biography

Emmanuel Mukwevho is a Professor of Biochemistry at the school of Chemical and Physical Sciences, at the NWU in South Africa. He has graduated for his PhD from University of Cape Town in June, 2010. He teaches Biochemistry in both undergraduate and postgraduate, especially Metabolism and Analytical Biochemistry. He has also obtained Certificates in Project Management and in Financial Management from UCT both in 2012. He is currently registered for MBA with NWU Graduate Business School.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords