alexa Advances In Clinical Studies On Anti-tumour And Supportive Care Effects Of Specific Mistletoe Preparations: Viscum Album [L.] Extract Therapy Versus No Antineoplastic Therapy In Patients With Locally Advanced Or Metastatic Pancreatic Cancer: A Randomized Clinical Trial (ISRCTN 70760582)
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

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3rd International Conference on Tissue Science & Regenerative Medicine
September 24-26, 2014 Valencia Convention Centre, Spain

Daniel Galun
Accepted Abstracts: J Tissue Sci Eng
DOI: 10.4172/2157-7552.S1.016
Abstract
Introduction: The patients with advanced pancreatic cancer have dismal prognosis. When deciding on specific treatment the impact on the quality of life should be taken into account. Objectives: To compare overall survival (OS) and quality of life (QoL) of patients with locally advanced or metastatic adenocarcinoma of the pancreas receiving Viscum album (L.) (VaL) or no antineoplastic therapy. Methods: The efficacy of VaL (Iscador?Qu special) was tested by a randomized clinical trial including 220 patients. Primary endpoint was OS observed over 12 month. Secondary efficacy parameters included all15 QoL-dimensions of the EORTC QLQ- C30. Tumour-related symptoms and body weight were recorded at each visit. Results: Median OS of VaL versus control was 4.8 vs. 2.7 months (HRadjusted=0.485; p<0.0001). A significant advantage of VaL was observed for 13 of the 15 QoL dimensions (p0.001), with 10 dimensions showing a clinically relevant improvement of ≥ 10 units. Analysis of tumour-related symptoms, and change in body weight (post-hoc), confirmed the favourable effects on QoL. No VaL-related adverse event (AE) or serious AE were observed. Conclusions: VaL therapy led to a relevant increase of OS and quality of life without causing any side-effects. VaL may provide a comprehensive second-line therapy for advanced pancreatic cancer patients
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