A variety of specialist databases have been developed to facilitate the study of allergens. However, these databases either
contain different subsets of allergen data or are deficient in tools for assessing potential allergenicity of proteins. Here, we
describe Allergen Atlas, a comprehensive repository of experimentally validated allergen sequences collected from in-house
laboratory, online data submission, literature reports and all existing general-purpose and specialist databases. Each entry was
manually verified, classified and hyperlinked to major databases including Swiss-Prot, Protein Data Bank (PDB), Gene Ontology
(GO), Pfam and PubMed. The database is integrated with analysis tools that include: (i) keyword search, (ii) BLAST, (iii) positionspecific
iterative BLAST (PSI-BLAST), (iv) FAO/WHO criteria search, (v) graphical representation of allergen information
network and (vi) online data submission. The latest version contains information of 1593 allergen sequences (496 IUIS allergens,
978 experimentally verified allergens and 119 new sequences), 56 IgE epitope sequences, 679 links to PDB structures and 155
links to Pfam domains.
Martti T Tammi is a research associate in Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden .He
did research work in department of Biological Sciences, National University of Singapore, Singapore and department of Biochemistry, National
University of Singapore, Singapore.His focused area is mainly Bioinformatics methods development: Large-scale genome sequencing methods,
sequence alignment, clustering and database search algorithms, pattern recognition, and comparative genomics.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals