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|Chonnam National University School of Dentistry Dental Science Research Institute, South Korea|
|Posters & Accepted Abstracts: Oral Health Dent Manag|
|Bisphosphonates (BPs) reduce bone loss by suppressing osteoclast activity and are currently used for the treatment of osteoporosis. As a side effect of BPs treatment, the emergence of osteonecrosis of the jaw (ONJ) has stimulated interest in understanding how BPs affect the bone, but far less understanding exists as to the ONJ mechanism. In the present study, it was hypothesized that BPs may affect the healing of alveolar socket by altering VEFG expression. In vivo osteoporosis rat models were made by bilateral surgical ovariectomy. Pamidronate (3.5 mg/kg/wk) was IP injected for 8 wks and the maxillary 1st molars were bilaterally extracted. For in vitro test, periodontal ligament cells were treated with pamidronate. Unexpectedly, VEFG-A and -B mRNA and protein levels were increased in in vivo and in vitro by the high concentration treatment. However, VEGF-C level was not changed. In the socket at day 7 after the molar extraction, the socket was filled with infiltration of neutrophils which showed strong immunoreactivity against VEGF. This result suggested that pamidronate treatment alters VEGF expression, which can be another mechanism of ONJ.|
Sun-Hun Kim is professor at Chonnam National University and chair of Dental Science Research Institute.
Email: [email protected]
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