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Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the
bioavailability of a range of poorly water-soluble drugs. Solid dispersions of poorly water-soluble drugs with water-soluble
carriers have been reduced the incidence of these problems and enhanced dissolution. Spray drying is an efficient technology
for solid dispersion manufacturing since it allows extreme rapid solvent evaporation leading to fast transformation of an APIcarrier
solution to solid API-carrier particles. Solvent evaporation kinetics certainly contribute to formation of amorphous solid
dispersions, but also other factors like the interplay between the API, carrier and solvent, solution state of the API, formulation
parameters (e.g. feed concentration or solvent type) and process parameters (e.g. drying gas flow rate or solution spray rate) will
influence the final physical structure of the obtained solid dispersion particles. The present study was carried out by using silica
adsorbents such as aerosil 200,sylysia 350 as carrier for solid dispersion preparation by spray drying technique. The conversion
of crystalline form of poorly water soluble API into amorphous form in silica based carrier results into enhanced dissolution rate
Dhanashri Yadav, doing M. Pharm. (Pharmaceutics) at Shivaji University, Kolhapur. She has presented various posters in national conferences and
has published two research articles in international journals. She is a Life Member of Indian Pharmaceutical Association.
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