alexa An Examination Of The Role Of Disulfide Bond Isomerase A Protein In Bacterial Virulence | 22269
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference and Exhibition on Cell & Gene Therapy

Sonal Malhotra
ScientificTracks Abstracts: J Stem Cell Res Ther
DOI: 10.4172/2157-7633.S1.007
Abstract
In the last two decades there has been a tremendous increase in number of bacterial genome sequencing projects. This effort has yielded a large collection of data that is freely available to researchers. The role of this study to perform selective and informed literature searches to establish the role of disulfide isomerases from different organisms in virulence in their respective hosts. DsbA and DsbA-like proteins have been implicated in bacterial virulence for a long time. Recently DsbA proteins have been implicated in biofilm formation or maturation in several bacterial species. Biofilms are relevant to the medical community. In particular, Bacterial cells in biofilm exhibit altered resistance to antibiotics. Furthermore biofilms comprising mixed populations of different bacterial species have been demonstrated on medical implant devices. Therapeutic intervention on such medical implants has been attempted. Disruption of dsbA gene in P. aeruginosa leads to a reduction in virulence in an animal infection model. We have recently shown that a dsbA disruption in P. aeruginosa PAO1 exhibits enhanced biofilm formation with respect to the wild type strain. This result is similar to results with P. putida: where adsbA disruption exhibits enhanced exopolysachharide and biofilm formation. In our simple biofilm assay examining gross biofilm formation: The kinetics of biofilm formation on plastic (petri dish) and aluminum are higher in the dsbA mutant with respect to the wild type strain. The similarity in findings between P. aeruginosa and P. putida support the notion ofconservation in the mechanisms of biofilm formation amongst different bacterial species. This lends credence to examining biofilm formation pathways in different bacterial species. Such a study will likely reveal conservation in mechanisms of biofilm formation and maturation. It is likely to pave the way for potential avenues for further research and therapeutic intervention. We will report here in this study some some key players in biofilm formation and any likely conserved mechanisms of biofilm formation. Further studies are likely to support a comparison of biofilm formation in a plant infection model (Wt and dsbA disruption mutant) and evaluation of biofilm formation on different materials.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7