alexa An In Vivo Biochemical Approach To Study The Delivery Enhancement Of Vitamin C And E Loaded Chitosan Nanoparticles Against Cisplatin Mediated Reproductive Toxicity In Male Sprague Dawley Rats
ISSN: 2161-038X

Reproductive System & Sexual Disorders: Current Research
Open Access

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2nd International Conference on Reproductive Health
December 01-02, 2016 San Antonio, USA

Humaira Rehman Jarral, Tariq Mahmmod, Ghazala Shaheen, Qurat Ul Ain, Imdad Ullah, Hizbullah and Sarwat Jahan
Quaid-i-Azam University, Pakistan
Posters & Accepted Abstracts: Reprod Syst Sex Disord
DOI: 10.4172/2161-038X.C1.003
Abstract
Present study was designed to investigate the potential of chitosan-based nanoencapsulation as a tool for delivering vitamin C and E to organisms. Vitamin C and E loaded chitosan nanoparticles (NPs) were made by ionic gelation and the particles were characterized. In present study, the biochemical mechanisms underlying possible protective effect of vitamin C and E loaded chitosan nano-particles on reproductive toxicity produce by cisplatin (CP) was examined. Twenty five male rats were divided into five groups: i) Control group received 0.9% saline, ii) Injection of CP (2 mg/kg) three days per week (i.p.), iii) Vitamin C and E (100 mg/kg) orally with CP (2 mg/kg), iv) Vitamin C and E loaded chitosan nano-particles (100 mg/kg) and, v) 50 mg/kg for 30 days along with CP (2 mg/kg). Animals were sacrificed and reproductive organs were removed for daily sperm production (DSP), biochemical analysis and comet assay. CP treatment resulted in a decrease in DSP, efficiency of sperm production, total protein concentration and level of antioxidants while increase in values of TBARS and ROS. CP exposed rats showed a significant damage to DNA. Vitamin C and E administration retreated some results but vitamin C and E loaded chitosan nano-particles resulted in significant reversal of above toxicities and damages. In conclusion, the nano-vitamin C and E may be useful to prevent CP-induced reproductive toxicity through its antioxidant potential.
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