alexa An Investigation In The Role Of Noncoding RNA’s In Epithelial Mesenchymal Transition (EMT) In Prostate Cancer
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

JOINT EVENT:19th Euro Congress on Cancer Science and Therapy & 25th Cancer Nursing & Nurse Practitioners Conference
July 17-19, 2017 Lisbon, Portugal

Hirendra Banerjee, William Kahan, Monet Stevention, Christopher Krauss, Preema Sarkar, Arghya Das, Mark Messmer, Brianna Morris, Ray Shawn Walker, Sasha Hodges, Narendra Banerjee, Alia Wofford and Myla Worthington
University of North Carolina, USA
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956-C1-105
Abstract
The recurrence and the metastasis of prostate cancer PCa are tightly linked with the biology of prostate cancer stem cells or cancer-initiating cells that is reminiscent of the acquisition of epithelial to mesenchymal transition (EMT) phenotype. Increasing evidence suggests that EMT-type cells share many biological characteristics with cancer stem-like cells (CSCs). In earlier studies it has been shown that there are certain genes and miRNA that are involved in this process. The genes and the miRNA have altered functionality causing this problem. We collected several prostate cancer samples from African American (AA) and Caucasian (CA) patients from Karmanos Cancer Center, Detroit, MI and compared the differential expression of those previously mentioned CSC related miRNA in these samples searching for biomarkers with clinicopathological variables, including race (AA vs. CA), to develop a clinically relevant algorithm for PCa aggressiveness. We identified that the over expression of genes Lin28B and EZH2 leads to the acquisition of the invasive characteristics of the Pca cells with EMT phenotype due to down regulation of miR200 and let7c, there by maintaining the stem cell like characteristics in PCa which in turn causes more aggressive PCa in AA than CA along with up regulation of the PRC2 (polycomb) protein complex expression. Work proposed in this application, will contribute to development of a novel theranostics approach involving the noncoding RNA’s that may translate into an effective treatment regimen against not only PCa but other cancers as well.
Biography

Hirendra Nath Banerjee completed his undergraduate degree in Biology & Chemistry and Bachelor of Medicine and Surgery degree from Calcutta University, India. His M.S. in Molecular Biology is from LIU at NY, USA and Ph.D. from Howard University Cancer Center in Washington, D.C. Dr. Banerjee did his post-doctoral training at Yale University and Medical University of South Carolina, USA. As a tenured Professor at Elizabeth City State University under the University of North Carolina system, Dr. Banerjee is involved in cancer research for more than two decades training many talented under graduate and graduate students in the process.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version