alexa An Isoflavone Compound Daidzein Elicits Myoblast Differentiation And Myotube Growth
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th World Congress on Pharmacology and Toxicology
July 24-25, 2017 Melbourne, Australia

Gyu-Un Bae
Sookmyung Women’s University, Republic of Korea
Posters & Accepted Abstracts: Clin Exp Pharmacol
DOI: 10.4172/2161-1459-C1-020
Abstract
The reduced regenerative capacity of muscle stem cells contributes to aging or disease-related skeletal muscle atrophy. Daidzein, a natural isoflavone from Leguminosae, improves insulin sensitivity in skeletal muscle and prevents TNF-α induced muscular atrophy. However, the molecular mechanisms by which daidzein exerts these beneficial effects are currently unknown. In this study, we determined the effect and molecular mechanisms by which daidzein might improve skeletal muscle function. Similarly to the results with TNF-α, daidzein treatment prevented myotube atrophy triggered by Dexamethasone (DEX) via Akt activation. Furthermore, daidzein promoted myoblast differentiation in a dose-dependent manner through activation of promyogenic kinases, Akt and p38MAPK. Daidzein treatment strengthened MyoD activation by enhancing its heterodimer formation with E protein. Additionally, daidzein induced myotube growth, through activation of Akt/mTOR/S6K pathway. Moreover, daidzein increased MyoD-dependent myogenic conversion of fibroblast and myogenic differentiation. Taken together, daidzein has a potential as a therapeutic or nutraceutical remedy to improve muscle function and to treat aging or disease-related muscle loss and weakness.
Biography

Gyu-Un Bae has completed his PhD from Sungkyunkwan University and Postdoctoral studies from Harvard University, School of Medicine. He has published more than 54 papers in reputed journals and has been serving as an Editorial Board Member of Archives of Pharmacal Research.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords