alexa An Umpolung Approach To The Asymmetric α-alkylation Of Aldehydes And Ketones
ISSN: 2150-3494

Chemical Sciences Journal
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

4th European Chemistry Congress
May 11-13, 2017 Barcelona, Spain

Don M Coltart
University of Houston, USA
Keynote: Chem Sci J
DOI: 10.4172/2150-3494-C1-007
The asymmetric alkylation of carbonyl compounds is a fundamental synthetic transformation. Remarkably, despite its importance, there is no general way to conduct this transformation in a catalytic asymmetric fashion. The umpolungbased alkylation of ketones and aldehydes wherein an organometallic species adds to an electrophilic carbon through the intermediacy of a derived azo- or nitrosoalkene provides an appealing approach to effecting this transformation. Not only does such an approach allow for the incorporation of functionality that cannot be introduced using enolate chemistry, but it is also well suited to catalysis and adaptable for asymmetric induction. Given the wide range of structures available as organometallic reagents (e.g., 1°, 2°, 3° alkyl, aryl, vinyl, alkynyl, etc.), this approach to catalytic asymmetric alkylation is also likely to prove broad in scope. Herein, we describe our recent efforts to exploit this mode of reactivity to provide a solution to the longstanding problem of developing a general, catalytic asymmetric approach to the alkylation of carbonyl compounds.

Don Coltart obtained his Master’s degree from the University of Manitoba under the supervision of Professor James L. Charlton, and he then joined the research group of Professor Derrick L. J. Clive at the University of Alberta where he obtained his Ph.D. His postdoctoral work was conducted at the Memorial Sloan-Kettering Cancer Center as an NSERC, AHFMR, and CRI Scholar under the supervision of Professor Samuel J. Danishefsky. Don began his independent career at Duke University in 2004 and moved to the University of Houston in 2012. His research group studies the development of methods for asymmetric carbon–carbon bond formation, the application of those methods to the total synthesis of structurally complex biologically active natural products, and the study of those compounds in biological systems.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version