Anal Melanoma: A Rare, But Catastrophic Tumor | 46819
Journal of Cancer Science & Therapy
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Introduction: Malignant melanoma of the anal canal is a rare and aggressive disease, whose early diagnosis is difficult. Its presentation
with no specific symptoms leads to a late diagnosis at an advanced stage. The prognosis of anorectal malignant melanoma is poor and
frequent related to distant metastasis and the absence of response of chemoradiotherapy. Surgery remains the mainstay of therapy;
otherwise the best approach is controversial. Considering no survival benefits for APR, wide local excision should be considered as
the treatment of choice.
Methods: This report collects nine cases of anorectal melanoma treated at our division from June 1977 to 2006, as well as a review of
Results: There were eight females and one male, of medium age 69 years (range: 41-85 years). Most frequent presentation was
bleeding, with two of them with amelanotic melanomas. Wide Local Excision (WLE) was performed in seven of them. Mean survival
was 24 months.
Conclusion: Anorectal melanoma remains challenging. Efforts should be taken to early diagnosis, and wide local excision with
negative margins is the preferred treatment. Abdominoperineal resection (APR) is a reasonable option for bulky tumors or when the
sphincter is invaded.