alexa Analysis Of Gut Microbiome In Patients With Acne Vulgaris
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

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16th European Dermatology Congress
June 07-08, 2017 Milan, Italy

Naoko Hitosugi
Muse Dermatology and Pain Clinic, Japan
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
DOI: 10.4172/2155-9554-C1-057
Abstract
Introduction: Acne vulgaris has long been postulated to feature a gastrointestinal mechanism. The human gut microbiota is a large microbial community, in which metabolites are shared among individual microorganisms. Recent studies demonstrate that various diseases are caused by certain component of bacteria in gut microbiome. The aim of this investigation is to evaluate the composition of gut microbiota of the patients who showed acne vulgaris. Method: Ten healthy women with acne vulgaris (Score <4; Inflammatory lesions are more apparent: many comedones and papules/ pustules, there may or may not be a few nodule-cystic lesions), ages between 20~25 were selected to evaluate the composition of gut microbiome. 10 healthy women without acne vulgaris (Score 0=Normal, clear skin with on evidence of acne vulgaris) ages between 20~25 were also evaluated as the control. Their faecal samples were collected and analyzed by deep sequencing of 16S ribosomal RNA by using gut microbiome detection kit (Mikinso Co. Ltd., Tokyo Japan). Those who had acne were treated by external use of antibiotics and other ointments such as benzoyl peroxide and adapalene to avoid any microbial substitution phenomenon by internal use. Result: The present study showed significant increase in Firmicutes in patients with acne vulgaris with low ratio of Bacteroides to Firmicutes compared to the control (63±5%, *p<0.05), whereas, there were no significant difference in Actinobacteria and Proteobacteria between the patients and the control. Discussion: Firmicutes is the bacteria that are known to decompose polysaccharides. Higher ratio of Bacteroides to Firmicutes has been linked to a healthier gut microbiota, since Bacteroides is involved to many of biosynthesis pathways such as B vitamins production. Further investigation is needed to show a casual association of acne vulgaris and Firmicutes.
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