Common pathogenic bacteria like E. coli, V. cholera and S. typhimurium display surface lectins that could be potentially
involved in pathogenesis. Due to the importance of these strains in causing the infectious disease, especially in developing
countries we performed an extensive analysis of the lectins displayed on pathogenic bacterial surfaces using ?BacterialLectinDb?.
Lectins from E. coli, V. cholera and S. typhimurium were compared to gain insights into the possibilities of common motifs that
could be responsible for contributing to host pathogen interaction. The various information about these lectins such as amino acid
sequence, gene name, PDB code etc. were obtained using Swiss-prot, SOPMA, Prodom, ClustalW etc. from ?BacterialLectinDb?.
Multiple sequence alignment using ClustalW was used to compare the protein sequences of the E. coli lectins F17a-G fimbrial
adhesion, Gafd (F17C-Type) fimbrial adhesion and and S. typhimurium lectin sialidase. Multiple sequence alignment of F17a-G
fimbrial adhesin and Gafd (F17C-Type) fimbrial adhesin both from E. coli show positive similarity with high score of 95.
Comparison of E.coli, F17a-G fimbrial adhesion and Gafd (F17C-Type) fimbrial adhesion lectin sequences to that of sialidase
from S. typhimurium generated a very low similarity score of only 1. These results thus point out to the role of these lectins in
host pathogen interactions.
Yashoda Mittal did Ph.D. from University of Roorkee (now IIT-Roorkee), India. They have authored several research papers, published a book and
developed 4 biological/lectins databases jointly.
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