Reach Us +44-1202068036
Anaplastic Large Cell Lymphoma, ALK-positive, Small Cell Variant, With Leukemic Presentation And Rare CD8-positive Phenotype | 19855
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Hematology & Blood Disorders

Dragos C Luca
ScientificTracks Abstracts: J Blood Disorders Transf
DOI: 10.4172/2155-9864.S1.006
Anaplastic large cell lymphoma (ALCL), anaplastic lymphoma kinase (ALK)-positive is a T-cell lymphoma consisting of usually large and pleomorphic lymphoid cells. The characteristic genetic abnormality is a translocation involving the ALK gene. The disease frequently involves both lymph nodes and extranodal sites but a leukemic presentation is quite rare. Of the broad morphologic spectrum of ALCL, one particular subtype, the small cell variant (5-10% of cases), may have a leukemic presentation with peripheral blood involvement. It is described a 16-year-old female patient who presented with fever, leukocytosis and lymphadenopathy. Initially, the peripheral blood smear examination was suggestive of leukemia. Subsequent flow cytometric analysis of the peripheral blood demonstrated an aberrant T-cell population but did not show an immunophenotype characteristic for a specific type of T-cell leukemia like T-cell prolymphocytic leukemia, adult T-cell leukemia, Sezary syndrome, etc. A bone marrow study was also performed and a smaller population of similar atypical cells was identified. Since the peripheral blood and bone marrow findings were not definitively diagnostic of a specific entity, a decision was made to obtain a lymph node biopsy. The normal lymphonodular architecture was almost completely effaced and, even though the majority of neoplastic cells were small, larger cells including "hallmark" and wreath-like cells were easily identifiable, suggesting a diagnosis of ALCL which was immediately confirmed by ALK immunohistochemistry and FISH analysis. Additionally, a rare CD8-positive phenotype was present by flow cytometry.
Dragos C Luca is the Director of Hematopathology and Flow Cytometry at Children?s National Medical Center and an Assistant Professor of Pathology and Pediatrics at George Washington University, both in Washington, DC. He is certified by the American Board of Pathology in Hematopathology, Pediatric Pathology and Anatomic/Clinical Pathology after completing his Pathology residency at the University of Illinois at Chicago with subsequent fellowships in Hematopathology at Loyola University and Pediatric Pathology at Northwestern University, both in Chicago. He has published in the fields of hematologic malignancies and pediatric solid tumors.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version