Reach Us +1-217-403-9671
Anti-allergic Effect Of Probiotic Dahi Containing Lactobacillus Acidophilus And Bifidobacteriumin Whey Proteins-induced Allegy Mouse Model | 4298
ISSN: 2155-9600

Journal of Nutrition & Food Sciences
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Anti-allergic effect of probiotic Dahi containing Lactobacillus acidophilus and Bifidobacteriumin whey proteins-induced allegy mouse model

International Conference and Exhibition on Nutritional Science & Therapy

Umesh Kumar Shandilya, Rajeev Kapila, S. Kapila and V. K. Kansal

AcceptedAbstracts: J Nutr Food Sci

DOI: 10.4172/2155-9600.S1.006

The present study was carried out to evalaute the effect of feeding probiotic Dahi on whey proteins (WP) allergenicity in mice. Probiotic Dahi were prepared by co-culturing in buffalo milk (3% fat) Dahi bacteria (Lactococcus lactis ssp. cremoris NCDC- 86 and Lactococcus lactis ssp. lactis biovar diacetylactis NCDC- 60) along with selected strain of Lactobacillus acidophilus LaVK2 (La-Dahi) or combined L. acidophilus and Bifidobacterium bifidum BbVK3 (LaBb-Dahi). Four groups of mice (8 each) were fed with the supplements (5 g/day) of buffalo milk (3% fat), Dahi, La-Dahi and LaBb-Dahi from 7 days before sensitization with WP (20μg/200μl PBS), respectively, in addition to milk protein-free basal diet, and a fifth group that received no supplements served as control. Feeding of probiotic Dahi suppressedthe elevation of whey proteins-specific IgE and IgG response in serum of WP-sensitized mice. In addition,sIgA levels were significantly (p<0.001) increased in intestinal fluid collected frommice fed with La-Dahi or LaBb-Dahi.Production of T helper (Th)-1 cell-specific cytokines, i.e. interferon-γ (IFN-γ), interleukin (IL)-12, and IL-10 increased, while Th2-specific cytokines, i.e. IL-4 decreased in the supernatant of cultured splenocytes collected from mice fed with probiotic Dahi compared to the other groups. Moreover,the splenic mRNA levels of IFN-γ, interleukin-10 were found to be significantly increased, while that of IL-4 decreased significantly in La-Dahi or LaBb-Dahi groups, as compared to control groups. Taken together, these results indicate that administration of La-Dahi and LaBb-Dahi might be useful for prevention of milk proteins allergy.