alexa Antibacterial Activity Of Recombinant And Synthetic Hepcidin | 69848
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd World Congress and Exhibition on Antibiotics and Antibiotic Resistance
July 31-August 01, 2017 | Milan, Italy

Marie-Agnes Sari
Paris Descartes University, France
ScientificTracks Abstracts: J Drug Metab Toxicol
DOI: 10.4172/2157-7609-C1-008
Abstract
Urinary Tract Infections (UTI), affecting 150 million cases per year worldwide, are the main cause of medical antibiotic prescription. However, uropathogen E. coli (UPEC) responsible for UTI are increasingly resistant to antibiotics, indicating urgent need for new therapeutic alternatives. The goal of our project is to explore hepcidin as a new antimicrobial peptide. Hepcidin is a cysteine rich, β defensin like peptide hormone that acts as the key regulator of body iron metabolism. Hepcidin regulates iron homeostasis in human through the binding of the sole iron exporter protein, ferroportin inducing its internalization prior degradation by lysosomes. Besides the liver that is the major source of bloodstream hepcidin, this peptide is expressed in epithelial barriers that are frequently confronted to pathogen infection, including kidneys. However, hepcidin belongs to defensins family and was observed to have an in vitro antimicrobial activity. We hypothesized that hepcidin was involved in host resistance to UPEC in renal epithelia where iron limit may be efficiently regulated. Hepcidin role against urinary tract infection was investigated using HepC-/-mice and synthetic hepcidin. Several recombinant hepcidins were produced as biologically active, ferroportin-binding peptide in E. coli, or yeast and synthetic hepcidin analogs were prepared and compared for their antibacterial activity on E. coli, B. subtilis and S. aureus. Bacteriostatic activity of hepcidin was demonstrated in vitro on CFT073 (a prototypical pyelonephritis-associated E coli strain). Evidence will be presented demonstrate that hepcidin is an effective mediator against UPEC infection and acts to prevent pathogenesis in the kidney in mice.
Biography

Marie-Agnes Sari is Professor of Biochemistry at Paris Descartes University and Head of the Laboratory of Chemistry and Biochemistry, Pharmacological and Toxicological research (UMR 8601 CNRS) and research interests are linked to metalloenzymes, or enzymes and peptides involved in metal transport, especially iron.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

nutriti[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version