alexa Antibacterial Properties Of Curtisia Dentata Leaves And Some Triterpenes/active Principles Isolated From Them
ISSN: 2161-0444

Medicinal chemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
December 08-10, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Fadipe V O, Mongalo N I and Opoku A R
Accepted Abstracts: Med Chem
DOI: 10.4172/2161-0444.S1.013
Abstract
Curtisia dentata leaves were collected from Buffelskloof Private Nature Reserve in Mpumalanga province (South Africa) in April 2014. C. dentata is traditionally used in the treatment of sexually transmitted infections, diarrhoea, stomach complaints and as a purgative. Dried leaves were extracted separately with ethanol, chloroform, diethyl acetate and acetone. The extracts were evaluated for antibacterial activity using micro dilution assay against ATCC strains of Escherichia coli, Pseudomonas aeruginosa, Mycobacterium smegmatis and some clinical isolates (Moraxella catarrhalis, Proteus mirabilis and Staphylococcus aureus) obtained from HIV patients at the Nongoma District hospital in KwaZulu-Natal Province. Ethanol, chloroform and acetone extracts of C. dentata exhibited lowest minimum inhibitory concentration (MIC) value of 0.78 mg/ml against P. aeruginosa, while diethyl acetate extract exhibited an MIC value of 3.13 against E. coli, M. catarrhalis, M. smegmatis and P. mirabilis. Two isolated compounds C. dentata ethanol extracts- pentacyclic triterpenes, ursolic acid (UA) and betulinic acid (BA) exhibited antibacterial activity. The BA and UA exhibited antibacterial activity with MIC values of 0.06 and 0.08 mg/ ml against S. aureus and P. mirabilis respectively. The observed biological activity of the extracts and the isolated compounds validates the use of C. dentata leaves in the treatment of various infectious diseases.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords