alexa Antibodies With Functionality As Unique Biomarkers And Targets In Drug Discovery And Regenerative Medicine
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th International Conference on Tissue Science and Regenerative Medicine
September 11- 12, 2017 Singapore

Sergey Suchkov, Noel Rose, Aleks Gabibov and Harry Schroeder
I.M. Sechenov First Moscow State Medical University, Russia
A.I. Evdokimov Moscow State Medical & Dental University, Russia
European Association for Prediction, Prevention and Personalized Medicine, Belgium
Johns Hopkins Medical Institute, USA
Institute of Bioorganic Chemistry-Russian Academy of Science, Russia
UAB-Division of Clinical Immunology & Rheumatology, USA
Moscow Engineering Physical Institute (MEPhI), Russia
ScientificTracks Abstracts: J Tissue Sci Eng
DOI: 10.4172/2157-7552-C1-036
Abstract
Catalytic Abs (catAbs) are multivalent immunoglobulins (Igs), endowed with a capacity to hydrolyze the antigenic substrate. In this sense, proteolytic Abs (or Ab-proteases) represents Abs endowed with a capacity to provide proteolytic effects. Ab-proteases were shown to occur at clinical courses and evidently correlate with the severity of the disease. A situation of much greater interest is occurred in multiple sclerosis (MS) which would demonstrate some new potential molecular targets to be selected for constructing newer diagnostic tools and setting up newer drug design as well. Anti-MBP autoAbs from MS patients exhibited sequence-specific proteolytic cleavage of MBP. The activity of Ab-proteases markedly differs: (1) Between MS patients and healthy controls, (2) Among MS patients with different types of the course to be the highest and thus dominate in a progradient course, progression phase, in particular. The activity of the Ab-proteases revealed significant correlation with scales of demyelination and thus with the disability of the patients as well. Moreover, when bursts of the Ab-associated proteolytic activity are evident, the pre-early stages of the exacerbation could be predicted, even at no seeing any clinical manifestations. And when we saw a stable growth of the activity, we could predict changing of a remitting type (moderate one) into the pro-gradient type (severe one) prior to changing of the clinical manifestations. Ab-mediated proteolysis of MBP results in generating a set of peptides. The final statistical data revealed six sites of preferential proteolysis. Most of those sites are located within the immunodominant regions of MBP. In contrast to canonical proteases, for Ab-proteases, there is an extra set of cleavage sites in the targeted autoantigens focused predominantly at the immunodominant sites of MBP. The activity of Abproteases was first registered at the subclinical stages 1-2 years prior to the clinical illness. About 24% of the direct MS-related relatives were seropositive for low-active Ab-proteases from which 38% of the seropositive relatives established were being demonstrating a stable growth of the activity for 2 years under the study. Moreover, low-active Ab-proteases in at-risk persons (at the subclinical stages) and primary clinical and MRT manifestations observed were coincided with the activity to have its mid-level reached. And registration in the evolution of highly immunogenic Ab-proteases to attack other sites predominantly would illustrate either risks of transformation of subclinical stages into clinical ones or risks of exacerbations to develop. Of tremendous value is Ab-proteases directly affecting remodeling of tissues with multilevel architectonics, for instance, myelin and by changing sequence specificity of the Ab-mediated proteolysis one may reach reduction of a density of points of the negative proteolytic effects within the myelin sheath and minimizing scales of demyelination. Moreover, Ab-proteases can be programmed and re-programmed to suit the needs of the body metabolism or could be designed for the development of principally new catalysts with no natural counterparts. So, further studies on Ab-mediated MBP degradation and other targeted Ab-mediated proteolysis may provide a supplementary (diagnostic, preventive and therapeutic) tool for assessing the disease progression, predicting disability of the patients and preventing the progression.
Biography

Sergey Suchkov has completed his graduation from Astrakhan State Medical University and awarded with MD, PhD at the I.M. Sechenov Moscow Medical Academy and Doctorship degree at the National Institute of Immunology, Russia. He was a Senior Researcher, Koltzov Institute of Developmental Biology and was the Head of the Lab of Clinical Immunology, Helmholtz Eye Research Institute in Moscow. Currently he is a Chair, Department for Personalized and Translational Medicine, I.M. Sechenov First Moscow State Medical University. He is a Member of the New York Academy of Sciences, USA; American Chemical Society (ACS), USA; American Heart Association (AHA), USA; EPMA (European Association for Predictive, Preventive and Personalized Medicine), Brussels, EU; ARVO (American Association for Research in Vision and Ophthalmology); ISER (International Society for Eye Research); and PMC (Personalized Medicine Coalition), USA.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords