alexa Anticancer And Apoptotic Effects Of Crocin Of Saffron And Cisplatin On Cervical Cancer Cells
ISSN 2472-0542

Journal of Experimental Food Chemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on Food Chemistry & Nutrition
July 24-26, 2017 Vancouver, Canada

Reyhane Hoshyar, Homa Mollaei and Mohammad Reza Abedini
Birjand University of Medical Sciences, Iran
Posters & Accepted Abstracts: J Exp Food Chem
DOI: 10.4172/2472-0542-C1-009
Abstract
Cervical cancer is one of the most common cancers among women worldwide. Nowadays, there are tendency to use natural products as alternative therapeutic agents. Anti-tumor effects of crocin as main of saffron carotenoids have been studied in several cancers but its molecular mechanisms of action are not fully understood. In this study, we investigate anti-proliferative and apoptotic activities of crocin combined with cisplatin on cervical cancer cells. To this aim, cell viability and apoptosis assays were monitored by MTT and Hoechst 33258 staining respectively. The mRNA levels of cell cycle (CyclinD1, P21 and P53) and apoptosis (Bax, Bcl-2) related genes were measured by qRT-PCR. Also, we assayed the expression of a microRNA (miR-365) as an upstream regulator of apoptotic genes. Our results showed that crocin in combination with cisplatin significantly (P<0.05) inhibited proliferation of cancer cells, induced apoptosis in cells at a dose- and time-dependent manner and decreased the effective dose of cisplatin. Furthermore, in treated cells Bax/Bcl-2 ratio and the mRNA level of P53 and P21 markedly increased (P<0.05), whereas expression of CyclinD1 and miR-365 decreased (P<0.05). Hence, it is suggested that crocin combined with cisplatin could be potentially used as an effective chemotherapeutic strategy.
Biography

Reyhane Hoshyar is working at the Birjand University of Medical Sciences, Iran. She is also the Member of Executive councilor committee for Food science Research Journal-an international Refereed Research Journal and Member of Executive councilor committee for Asian Journal of Home Science-an international Refereed Research Journal.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords