alexa Anti-diabetic Activity Of Nigella Sativa Oil Through Its Effect On Some Enzymes And Signaling Molecules In Streptozotocin-induced Diabetic Rats
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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9th Annual European Pharma Congress
June 26-28, 2017 Madrid, Spain

Mahmoud Balbaa
Alexandria University, Egypt
Posters & Accepted Abstracts: Pharmaceut Reg Affairs
DOI: 10.4172/2167-7689-C1-025
The black seeds of Nigella sativa have different biological activities and the anti-diabetic effect is among these activities. Streptozotocin (STZ)-induced diabetic rats were treated daily with NS oil (NSO) in order to study the effect on some enzymes and the expression of some insulin receptor-induced signaling molecules. The administration of NSO to STZ-induced diabetic rats induced significantly the activity of arylsulfatases and enhanced the antioxidant enzymes. Moreover, it significantly induced the gene expression of insulin receptor compared to non-treated rats. This treatment of NSO was combined also with some drugs (metformin and glimepiride) and an insulin receptor inhibitor; also, it upregulated the expression of insulin like growth factor-1 and phosphoinositide-3 kinase; whereas the expression of ADAM-17 was downregulated and TIMP3 was upregulated. The obtained data markedly confirmed antidiabetic effect of NSO on antioxidant activity and signaling molecules in the absence and presence of some anti-diabetic drugs. In conclusion, diabetes induces significant alterations of the catalytic characters of arylsulfatases and some oils decrease this alteration through an antioxidant-mediated effect. Moreover, NSO has a potential in the management of diabetes through the modification of insulin-induced signaling and the interaction between herbs and drug.

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