Farjana Islam Aovi
Daffodil International University, Bangladesh
The present study was aimed to evaluate the anti diabetic activity potential of Pandanus foetidus aerial root against streptozotocin (STZ) induced experimental rats. Ethanolic extract of aerial root of Pandanus foetidus (EEPF) was administered to streptozotocin induced rats. Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Pandanus foetidus (400 mg/kg b.wt) in diabetic groups. Blood glucose levels were determined on 0, 7th, 14th and 21st day after oral administration of ethanolic extracts of Pandanus foetidus (400 mg/kg). An ethanolic extract of Pandanus foetidus was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Pandanus foetidus on serum lipid profile like total cholesterol, triglycerides, low density, very low density and high density lipoprotein were also measured in the diabetic and non diabetic rats. There was significant reduction in total cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. These results indicated that Pandanus foetidus possesses a hypoglycemic and antihyperlipidemic effect.
Email: farjana.pharm@diu.edu.bd
