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ery important determination of risk disease is a diet. Prebiotics are nutrients that have the potential to considerably influence
the physiology of whole body, health, and well-being. In addition to Prebiotics are used widely because of their properties of
to increase the numbers of bacterial strains such as bifidobacterium or lactobacillus. Consumption of oligosaccharide raises the
population of the gram- negative bacteria such as Bifidobacteria and lactobacilli which plays an important role in prevention of
many diseases and maintaining good health. Oligosaccharides such as Inulin have been demonstrated to be effective prebiotics.
This has been shown through
assessments in laboratories. In this study of Antigenotoxicity of Inulin, strain of gram-
were incubated with suitable mutagen i.e. Amaranth and DNA damage was measured using the
fluctuation test. Study analyses the DNA damage of E. coli (rifampicin resistant) by using fluctuation test. During the tests results
indicate that DNA damage has been significantly decreased in presence of inulin. Practical data shows that during the decrease in
the concentration of the mutagen increase the mutation rates. This increase in mutation rates means there is an induce mutation
in E.Coli. Study during the experiment shows that when the different concentration of inulin is given with mutagen it decrease
the mutation rates that means there is a positive evidence of antigenotoxic activity of the prebiotics i.e. Inulin. From the above
evidence, practically it can be conclude that inulin possesses antigenotoxic or anti-carcinogenic effect against the cellular DNA
Ronakkumar Patel is studying Master of Toxicology in University of East London, UK. During his summer period of university, he has done research
on Anti-genoxicity of prebiotics under the guidance and support of Professor Dr. Wintson A. Morgan. Dr. Morgan is currently a Principal Lecturer in
Toxicology and Biomedical Science, also program leader for the 9 MSc Bioscience masters programs in University of East London.
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