Kalakotla Shanker, Gottumukkala Krishna Mohan, Ashfaq Hussain and Pravallika P L
Jawaharlal Nehru Technological University, Hyderabad, India
Pullareddy Institute of Pharmaceutical Sciences, Medak, India
Diabetes is a metabolic disorder characterized by hyperglycemia, carbohydrates, altered lipids and proteins metabolism. In recent research, biological methods have been used to synthesize silver nanoparticles in presence of medicinally active antidiabetic plants extensively used in treatmemt of diabetes and this intention made us to assess the biologically synthesized silver nanoparticles from the fruit extract of Momordica charantia using 1 mM silver nitrate solution. The biologically synthesized silver nanomedicine (BSSNP) then subjected to various characterization techniques like XRD, SEM, EDX, TEM, DLS, UV and FT-IR respectively. In current study, the silver nanoparticles tested for in-vitro anti hyperglycemic activity and possible toxic effects in healthy female albino mice was studied. The result obtained from histopathological sectioning was in agreement as there was no apparent damage to the heart, liver and pancreas observed in the treated groups when compared with the control group. BSSNP was successfully obtained from bioreduction of silver nitrate using Momordica charantia plant extract and have been appropriately characterized using different equipments. In current study, the silver nanoparticles were tested for in-vitro anti diabetic activity. PTP1B assay has been done to determine the initial antidiabetic activity of BSSNP. It may be concluded that the medicinal plants can be good source for synthesis of BSSNP. In-vivo parameters need to be carried out further.
Kalakotla Shanker completed MPharmacy from JNT University Hyderabad and is currently pursuing 3rd year of full time PhD in JNT University Hyderabad, India. He has published more than 11 papers in international peer reviewed reputed journals.
Email: shankerkalakotla@gmail.com
