Reach Us +44-1477412632
Antihyperlipidemic Effect Of Esculetin On Lipid Metabolism In Experimental Diabetic Rats | 6161
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Antihyperlipidemic effect of Esculetin on lipid metabolism in experimental diabetic rats

3rd World Congress on Diabetes & Metabolism

D. Prabakaran and N. Ashokkumar

Posters: J Diabetes Metab

DOI: 10.4172/2155-6156.S1.019

Diabetes mellitus is a significant risk factor for cardiovascular complications. This study was undertaken to investigate the effect of esculetin on plasma glucose, lipid profile and enzymes involved in lipid metabolism in streptozotocin-induced diabetic rats. Diabetes was induced in adult male albino rats of the Wistar strain, weighing 200?220g by administration of streptozotocin (40 mg/kg of body weight) intraperitoneally. Diabetic rats exhibited increased blood glucose with significant decrease in plasma insulin levels. Elevation in the levels of total cholesterol, triglycerides, free fatty acids, phospholipids were increased in plasma and tissues (liver and kidney) and low density lipoprotein-cholesterol and very low density lipoprotein-cholesterol, and decreased high density lipoprotein-cholesterol were found in diabetic rats. In addition, the activity of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase increased significantly in the liver and kidney whereas the activities of lipoprotein lipase and lecithin cholesterol acyl transferase were decreased significantly in the plasma of diabetic rats. Treatment with esculetin at a dose of (40 mg/kg body weight) for 45 days altered the above changes and improved towards normal. These findings suggest that esculetin treatment has a therapeutic property by showing antihyperglycemic and antihyperlipidemic effect on STZ-diabetic rats.