Anti-inflammatory Effect And Toxicology Analysis Of Oral Delivery Quercetin Nanosized Emulsion In Rats | 56714
Journal of Clinical Toxicology
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This study evaluates the advantage of the quercetin encapsulation in nanosized emulsion (QU-NE) administered orally
in rats in order to demonstrate its anti-oedematous and antioxidant effects as well as its toxicity. The nanocarriers were
prepared using the hot solvent diffusion with the phase inversion temperature methods. The nanocarriers physicochemical
properties were then investigated. The anti-edematous activity was tested using paw edema in rats. In addition, NF-kB
expression in subcutaneous tissue of the paws was accessed by immunohistochemistry while the lipid peroxidation was
analyzed in the liver by malondialdehyde reaction with thiobarbituric acid. Hematological, renal and hepatic toxicity as well
as the genetic damage were also evaluated. The results demonstrated that QU-NE exhibited pronounced anti-oedematous
property comparable to drug diclofenac. This effect was associated with NF-κB pathway inhibition. The lipid peroxidation was
also only reduced in rats treated with QU-NE. Besides this, no genetic damage, hematological, renal or hepatic toxicities were
observed after administration of QU-NE. These results suggest that quercetin nanosized emulsion exhibits anti-oedematous
and antioxidant properties and does not demonstrate toxic effects. This indicates that it has a potential application in the
treatment of inflammatory diseases.
Gabriela Hädrich is pursuing her PhD from Federal University of Rio Grande, Brazil. She is a visiting PhD student at Martin-Luther Universität Halle-Wittenberg, Germany. She has completed her Master degree in Health Sciences in 2014 and has expertise in Nanotechnology applied to health and microbiology.