Anti-phytopathogenic and anti-cytotoxic brominated sesquiterpenes from the Indonesian red seaweed Laurencia intricata

2^nd World Chemistry Conference

August 08-10, 2016 Toronto, Canada

Kasmiati, Yukio Yoshioka, Tetsuji Okamoto and Makoto Ojika

Nagoya University, Japan
Hiroshima University, Japan

Posters & Accepted Abstracts: Chem Sci J

Abstract :

Marine natural products have been providing structurally novel bioactive substances, some of which were developed as medicines or were promising leads for new drugs. During the search for bioactive substances from marine organisms, we detected anti-phytophatogenic (an oomycete of Phytophthora) activity for extracts of the Indonesian red seaweed Laurencia intricata. The active hexane and 90% methanol extracts were combined and separated on silica gel and then purified by reversedphase HPLC to obtain four related compounds. Based on 2D NMR and MS analysis, they were identified as aplysistatin, palisadin A, palisol, and 5�²-hydroxypalisadin B, which are all known brominated sesquiterpenes. The minimum doses to inhibit Phytophthora capsici are 100, 300, 300, and 300�µg/disk respectively. Cytotoxic activity of these compounds was also evaluated against human epidermoid carcinoma A431 cells, showing the IC50 values of 0.15, 1.42, 0.59, and 0.45�¼g/ml respectively.

Biography :

Kasmiati is a PhD candidate at Nagoya University Graduate School of Bioagricultural Sciences, field of Bioactive Natural Products Chemistry. She is a young Lecturer at Hasanuddin University Indonesia, Faculty of Marine Sciences and Fishery. She has presented related papers both poster and oral in some international conferences.
Email:kasmiati74@yahoo.com