alexa Antiproliferative Effect Of Main Dietary Phytosterols And/or β-cryptoxanthin In Human Colon Cancer Caco-2 Cells Through Cytosolic Ca2+ - And Oxidative Stress-induced Apoptosis
ISSN: 2155-9600

Journal of Nutrition & Food Sciences
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

3rd International Conference and Exhibition on Nutrition & Food Sciences
September 23-25, 2014 Valencia Convention Centre, Spain

Antonio Cilla, Alessandro Attanzio, Luisa Tesoriere, Maria A Livrea and Reyes Barbera
ScientificTracks Abstracts: J Nutr Food Sci
DOI: 10.4172/2155-9600.S1.012
Scope: Phytochemicals such as β-cryptoxanthin (β-Cx) and phytosterols (Ps) have been known for possessing beneficial effects related to bone health and cholesterol disorders, respectively. More recently, these bioactive compounds have gained attention for their potential role against different types of cancer, including colon cancer. However, their combined action has not been reported so far. Methods and results: Human colon cancer Caco-2 cells were treated 24 h with β-Cx and/or major dietary Ps (β-sitosterol, campesterol and stigmasterol), alone or in combination, at concentrations compatible with physiological human serum levels. A decrease in cell viability due to apoptosis (rise in sub-G1 population and exposure of membrane phosphatidylserine) was accompanied with dephosphorylation of BAD, mitochondrial depolarization and caspase 3-dependent PARP cleavage, with intracellular Ca2+ influx and increase of ROS levels as initial triggers. Conclusion: Ps and β-Cx, alone or in combination have shown anti-proliferative activity against human colon adenocarcinoma Caco-2 cells through the mitochondrial pathway of apoptosis. No additive or synergistic effects have been observed. It is stressed the importance of bioactivity-guided assays with mixtures of dietary compounds to determine their eventual interactions in the food context.
Antonio Cilla obtained his PhD in Food Science in 2010 at the University of Valencia. He performed predoctoral research stays in CEBAS-CSIC (Murcia-Spain) with Dr. Francisco Tomas-Barberan and Juan Carlos Espin (2007) and in ICTAN-CSIC (Madrid-Spain) with Dr. Laura Bravo (2009), and a postdoctoral stay in STEBICEF lab (Palermo-Italy) with Dr. Maria Antonia Livrea and Luisa Tesoriere (2014). He is now Senior Research Technician at the University of Valencia and Assistant Professor of Nutrition at the University Cardenal Herrera-CEU. He has authored 22 journal manuscripts, 7 book chapters and a number of conference publications in Food Science and Nutrition area. He is an active reviewer and editorial board member for a number of prestigious international journals.
image PDF   |   image HTML
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version