alexa Apoptin Enhances The Oncolytic Properties Of Vaccinia Virus And Modifies Mechanisms Of Tumor Regression By Virus
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

4th World Congress on Virology
October 06-08, 2014 Hilton San Antonio Airport, TX, USA

Sergey Netesov, Galina Kochneva, Evgeniy Zonov, Antonina Grazhdantseva, Anastasiya Unusova, Galina Sivolobova, Evgeniy Popov, Oleg Taranov, Peter Chumakov and Elena Ryabchikova
ScientificTracks Abstracts: J Antivir Antiretrovir
DOI: 10.4172/1948-5964.S1.020
Some effective oncolytic viral recombinant strains engineered on the base of adeno-, herpes and vaccinia (VACV) viruses have been recently reported. We constructed apoptin-producing recombinant VACV based on L-IVP vaccinia strain in which the apoptin gene was inserted instead of deleted C11R-gene encoding viral growth factor. The obtained recombinant VVdGF-ApoS24/2 effectively produced apoptin in the infected cells, and demonstrated a significantly greater lytic activity on cancer cell lines (А549, А431, U87MG, RD and MCF7) as compared with parental L-IVP. The oncolytic effect was examined by virological, light and electron microscopy methods. Regression of the tumor after L-IVP strain injection was accompanied with formation of cavities filled with cell debris and liquid, while apoptin-producing strain caused shrinkage of the tumor. Surprisingly, the immunohistochemical analysis has revealed that unlike the previously described preferentially nuclear localization of apoptin in cancer cells, the apoptin produced by the VVdGF-ApoS24/2 is localized to the cytoplasm. We suggest that apoptin expressed by VVdGF-ApoS24/2 does not induce a typical apoptosis, but rather modified the virus-induced cell death in such a way that the tumors shrink without the excessive formation of cell debris and exudates.
image PDF   |   image HTML
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version