alexa Application Of Embryogenic Mouse As A Platform In Identifying Human Missing Proteins
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th International Conference on Proteomics and Bioinformatics
May 22- 24, 2017 Osaka, Japan

Bin Huang
Kaohsiung Medical University, Taiwan
ScientificTracks Abstracts: J Proteomics Bioinform
DOI: 10.4172/0974-276X-C1-097
Abstract
Missing proteins are those genes with detectable transcriptional mRNA while missed in detecting translational proteins no matter by western blot or mass spectrometry. To date, missing proteins are regarded as a “KEY” in triggering the early stage of many responses and then disappear once these signaling cascades have been turn on. That’s why missing proteins are always “MISSED” in numerous tissues. Embryo contains many definitive genes, which might be the missing protein, that temporarily control the subsequent organogenesis. Since the decoding of human and mouse whole genomes were completed, the similar protein sequence appears in mouse can mostly be identified in human database. The embryos taken from mice after pregnant for 6.5, 7, 7.5 and 8 days, the stage for the onset of neuron plate formation were analyzed by mass spectrometry. There were 6/127 missing proteins located on chromosome 4 identified, including unnamed proteins, TMEM155 precursor, mutant enamelin, uncharacterized protein C4orf51 and THAP domain-containing protein 6. These missing proteins exhibited a possible implication in neural system development. In addition to Chromosome 4, a software facilitates the algorithm matching of 23 chromosome from mass spectrometric raw data and human database was designed. As a result, embryonic mice could be the most suitable platform for detecting missing proteins and elucidating their role in organogenesis.
Biography

Bin Huang gained his PhD degree from Department of Plant Science, National Taiwan University. He also trained by Cardiology during his Post-doctoral fellowship. Now he has expertise in gaseous molecules-mediated post-translational proteome and also the behaviors of mitochondrial fusion/Fission that evaluating cell aging and cancer cell drug-resistance. In addition to general research interests, he also has an administrative duty as a Vice Chief of Center for Stem Cell Research of Kaohsiung Medical University.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords