alexa Application Of Quantitative Metabolomics In Human Maternal, Prenatal, And Neonatal Disease Biomarker Studies
ISSN: 2153-0769

Metabolomics:Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Metabolomics & Systems Biology
March 24-26, 2014 Hilton San Antonio Airport, San Antonio, USA

David Wishart
Accepted Abstracts: Metabolomics
DOI: 10.4172/2153-0769.S1.026
Abstract
Metabolomics has shown significant promise for the discovery of new biomarkers for the detection of a number of complex clinical disorders. However, the use of metabolomics in obstetrics is a relatively new phenomenon. The Metabolomics Innovation Centre (TMIC), Canada?s national metabolomics platform, specializes in performing quantitative metabolomics assays on human biofluids using a wide range of technologies.Recently, TMIC has participated in several maternal, prenatal and neonatal disease biomarker studies, including pre-eclampsia (PE), Trisomy 18 and 21, and HypoxicIschaemic Encephalopathy (HIE). NMR based metabolomic analysis was performed on first trimester maternal serum between 11-13 6/7 weeks of gestation in a case-control study, including 30 cases each of early and late onset PE and 60 unaffected controls. The concentrations of 40 metabolites were compared between the two groups. In both studies significant differences in the first-trimester metabolites were noted in women who had subsequently developed early- and late-onset PE. NMR based metabolomic analysis of maternal serum was also applied to determine whether the metabolomic profile is altered in Trisomy 18 and 21 pregnancies and whether these maternal serum biomarkers can predict Trisomy 18 and Trisomy 21. In both studies, NMR analyses of maternal serum showed an extensive group difference in metabolomic profile indicating the application of metabolomics as a novel tool for aneuploidy prediction. A combined DI and LC-MS/MS approach was used for metabolomic profiling of umbilical cord blood in neonatal HIE. The study population was divided into those with confirmed HIE (n=31), asphyxiated infants without encephalopathy (n=40) and matched controls (n=71). Our results showed a significant alteration between study groups in 29 metabolites from 3 distinct classes (amino acids, acylcarnitines and glycerophospholipids). This study highlights the potential for metabolomic technology to develop a diagnostic test for HIE. These applications will be presented in detail. Here we intend to show the potential that metabolomics holds in contributing to the understanding of maternal and neonatal health.
Biography
David Wishart is the Director of The Metabolomics Innovation Centre (www.metabolomicscentre.ca) and a Professor at the University of Alberta in the Department of Chemistry and the NRC National Institute for Nanotechnology. He has pubished more than 250 scientific articles, and has successfully led many national and international research initiatives in biotechnology and nanotechnology, including the Human Metabolome Project (http://www.metabolomics.ca). His research interests are very broad, with the areas relating to nanobiology, genomics, proteomics, metabolomics, bioinformatics and systems biology. His particular interests lie in developing novel methods or improved experimental techniques to facilitate the understanding of biological systems at the molecular (or nano) scale.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords