Journal of Drug Metabolism & Toxicology
Open Access

Application of small synthetic antimicrobial peptides (ssAMP) to control antibiotics resistant pathogens of citrus canker disease

3^rd World Congress and Exhibition on Antibiotics and Antibiotic Resistance

July 31-August 01, 2017 | Milan, Italy

Jaehyuk Choi, Jae-Wook Hyun, Hyun-Joo An and Kwang-Hyun Baek

Yeoungnam University, South Korea
Citrus Research Station, South Korea

Posters & Accepted Abstracts: J Drug Metab Toxicol

Abstract :

Citrus canker caused by Xanthomonas Citri Subsp. Citri (Xcc) decreases the fruit quality and yield significantly. Emerging of Streptomycin-Resistant (SR) strains threatens the citrus industry seriously because of a lack of proper control agents. It has been suggested that ssAMPs could be a promising alternative. Over 50 potential hexapeptides were designed and synthesized based on the Positional Scanning of Synthetic Peptide Combinatorial Libraries (PS-SPCL). Majority of them showed antimicrobial activities against variety of microbes including Bacillus, Pseudomonas, Xanthomonas and Candida species. Three hexapeptides, BHC06 and 11, and KCM21 were selected and tested to control citrus canker using 5 years old sathuma mandarin leaves (Citrus unshiu). Each hexapeptide drastically reduce the canker symptom development caused by wild type as well as SR strains. The results showed great potential of ssAMPs to fight against emerging antibiotics-resistant pathogens in agriculture.

Biography :

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