alexa Aqueous Extracts Of Citrus Sinensis Have Anti Hyperglycemic Effects That Challenge Glibenclamide, An Anti-diabetic Drug | 62780
ISSN 2472-1042

Pharmacoeconomics: Open Access
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

11th World Congress on Pharmaceutical Sciences and Innovations in Pharma Industry

Boris K G Azantsa, Imelda Lucresse N Djuikoo, Edwidge Dibacto, Judith Ngondi and Julius Oben
University Of Yaounde I, Cameroon
Posters & Accepted Abstracts: Pharmacoeconomics
DOI: 10.4172/2472-1042.C1.003
Abstract
Managing type 2 diabetes mellitus and its complications in Africa and all over the world remains a big challenge. Hyperglycemia associated with insulin-resistance is the main pathogenic mechanism that leads to structural alterations. It can cause all of the diabetes-related complications, with the formation of advanced glycation end products. Despite all the therapies used since the past decade, in Africa and Asia T2DM patients are desperately using herbal medicines because of cost and side effects. The present study aimed at determining the anti-hyperglycemic effects of leaves and bark aqueous extracts of Citrus sinensis on normal Wistar rats. Citrus sinensis was harvested from Yaoundé; bark and leaves were isolated, dried and blended into powders. Maceration of each powder in water was done for 48 h to obtain aqueous extracts: Citrus sinensis leaves and Citrus sinensis bark. The antihyperglycemic activity was evaluated in vivo through oral glucose tolerance test. Twenty Wistar male rats, of 150-180 g were used. After an overnight fasting, their glycaemia were measured (T0). They were distributed into four groups receiving: Positive Control [water only], Test 1 [400 mg/kg Citrus sinensis leaves], Test 2 [400 mg/kg bw Citrus sinensis bark] and Reference [4 mg/kg bw glibenclamide] as anti-diabetic drug. Thirty minutes later, an overload of 2 g/kg bw of glucose was administered to all the groups. Blood glucose was measured through tail pricks at: 30, 60, 90, 120 minutes using a glucometer. Results showed that Citrus sinensis leaves and Citrus sinensis bark were able to reduce glucose load within two hours more efficiently than PC and interestingly than glibenclamide (Figure 1). Calculated AUC (mg.min.dL-1) were 4015, 873.8, 786.6, 1163 respectively for PC, C.s leaves, Citrus sinensis bark and glibenclamide confirm the efficacy of extracts. Aqueous extracts of C. sinensis are capable to reduce postprandial glycaemia, challenging glibenclamide as diabetic drug. The extracts could thus be further explored for their potency in the treatment of T2DM.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7