alexa Assessing Resistance Of Bacterial Pathogens To Pharmaceutical Medications
ISSN: 2161-0932

Gynecology & Obstetrics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

International Conference on Pediatrics & Gynecology
6-8 December 2011 Philadelphia Airport Marriott, USA

Shayo Onundi
Accepted Abstracts: Pediatr Therapeut
DOI: 10.4172/2161-0665.S1.06
Abstract
Background: Pulmonary hypertension (PH) associated with congenital diaphragmatic hernia (CDH) remains a signifi cant cause of morbidity and mortality. For improved outcomes, preoperative stabilization is commonly practiced to control the PH in infants with CDH. Some CDH infants who have been considered stabilized and ready for surgery have nevertheless developed signifi cant PH aft er surgical repair. In fact, the markers and consequences of the preoperative stabilization are still unclear. Th erefore we examine the peri-operative course of PH to evaluate the impact of preoperative PH severity on mortality and morbidity of infants who underwent surgical repair of CDH. Methods: Th e medical charts of all newborns (n = 49) with CDH who were treated at our institution between January 2000 and December 2009 were reviewed. General management and perioperative data were evaluated for all infants. Th e ratio of estimated pulmonary artery pressure to systemic pressure (P/S ratio or PSR), based on echocardiographic data, was used to assess the PH severity during the perioperative period. Results: Th e overall survival rate in our group of infants with CDH was 71.4%. Of the 49 infants with CDH, 9 (18.4%) died during the preoperative phase. Forty infants underwent CDH repair at a median age of 3.5 days (range, 1 to 46 days). Five of these infants (12.5%) subsequently deteriorated and died aft er surgery. Using ROC analysis, a PSR cut-off value prior to surgery of 0.9 predicted mortality in CDH infants, with a sensitivity of 100% and specifi city of 84% and with an area under the curve (AUC) of 0.93 (P=0.002). Accordingly, two groups of infants with distinct outcomes were identifi ed, as follows: a low-PSR cohort (PSR≤0.9) with a survival rate of 100% and a high-PSR cohort (PSR>0.9) with a survival rate of 50% (P=0.001). Th e rate of pneumothorax and the frequency of use of several inotropic agents aft er surgery were signifi cantly higher in the high-PSR group (P=0.001 and 0.007, respectively). Compared with low-PSR infants, infants with high PSR were operated on later (P=0.03) and were postoperatively ventilated for longer (P=0.01). During the entire perioperative period, signifi cant diff erences in the PH severity were noted between the two PSR groups. During the fi rst week of life, infants in the high-PSR group had signifi cantly higher PSRs than those in the low-PSR group (P=0.001), and similar tendencies continued to be signifi cant between the two groups aft er CDH repair (P=0.04). Conclusions: During the perioperative period, PH severity monitoring via the serial assessment of PSR is benefi cial. Better outcomes were observed with a preoperative PSR≤0.9, and this association needs to be confi rmed by prospective study
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version