alexa Assessment Of Peripheral Blood Immunoglobulins (IgG, IgM & IgA), Lymphocyte Subsets (T & B Cells) And Natural Killer Cells In Children With Down Syndrome | 19692
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference and Exhibition on Clinical & Cellular Immunology

Sheetal Sharda
Accepted Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899.S1.019
Abstract
Down syndrome (DS) is the most frequent cause of mental retardation with an incidence of approximately 1 in 800 live births. Individuals with DS are cognitively impaired, although severity is highly variable. Characteristic facial features and hypotonia are present in almost all patients. Abnormalities of the cardiovascular system, gastrointestinal tract, eye and ear abnormalities occur with increased frequency compared with non-Down syndrome patients (NDS). It has been known that subjects with DS have an increased susceptibility to bacterial and viral infections, a high risk of malignancies, and autoimmune disorders in comparison to healthy population. Autoimmune phenomenon such as acquired hypothyroidism, celiac disease and diabetes mellitus also occur at higher frequency compared with NDS. Leukemia and pneumonia are still the major causes of mortality and morbidity in these children. The increased susceptibility to infection, malignancies and autoimmune disease, suggest that immunodeficiency is an integral part of DS. However, a majority of them do not show clear features of immunological disease. Multiple immunologic disturbances are commonly observed in individuals with DS including abnormal proportions of peripheral lymphoid subsets, cellular dysfunction and autoimmune phenomena. The abnormalities of the immune system associated with DS include: Mild to moderate T and B cell lymphopenia, with marked decrease of naive lymphocytes, impaired mitogen-induced T cell proliferation, reduced specific antibody responses to immunizations and defects of neutrophil chemotaxis. The clinical relevance of these immunological disturbances is also unclear. Although a high incidence of infectious diseases, particularly viral hepatitis and upper-tract respiratory infections in DS, is currently reported in the literature, the existence of an immunodeficiency associated to DS is not firmly established. There is no clear evidence of enhanced susceptibility to infection, suggestive of serious immunodeficiency, in both adults and children with DS, in spite of the existence of compelling evidence of immune derangement. Life expectancy in DS is significantly poorer than that for the general population, but over half of DS individuals can be expected to survive into their 50?s. Deaths from infection have shown the largest decline because of improvements in the health care provision. There is lack of data regarding the immunologic status of children with DS in India. At present there are no recommendations or guidelines to routinely investigate these children for immunological abnormalities, thus increasing the morbidity due to recurrent infection and also autoimmune disorders. The study is designed with an aim to determine the relationship between abnormalities in immune system with relation to peripheral blood lymphocytes and their subsets and immunoglobulin levels in children with DS, thus giving us an opportunity to identify those groups of patients with severe abnormalities and instituting improved care .
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7