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Long-term use of bisphosphonates (BP) is associated with the risk of BP-related osteonecrosis of the jaw (BRONJ). The number
of post-menopausal women receiving BP therapy for osteoporosis continues to increase as the life expectancy increases. Dental
implant rehabilitations have progressed over the years. The purpose of this study was to evaluate the peri-implant conditions of
patients taking oral or intravenous (IV) BPs. This was a retrospective study using an ORACLE database search by means of a
Procedural Language/Structured Query engine. Fifty female patients with dental implant rehabilitations and taking bisphosphonates,
and fifty female patients with dental implants but not taking BP were evaluated. Peri-implant health and rehabilitation conditions
were collected and statistics analyzed. Data analysis revealed a strong indication (p<0.01; 82.81%) of the existence of association
between abscesses and the use of bisphosphonates. Relative risk indicated 25 times more chance of a person that does not use
bisphosphonates to develop abscess when compared with people using bisphosphonates. This shows that the use of bisphosphonates
may play a protecting role in the patients with dental implants. Alternatively, there was a strong indication (p<0.01) of existence of
association between the occurrence of mucositis and the use of bisphosphonates. Most of the cases of mucositis (94.44%) occurred
in patients that used bisphosphonates while the majority of the cases where mucositis did not occur (59.76%) referred to the group
being treated with bisphosphonates. This study revealed that there were not indications of significant associations between doses of
bisphosphonates and the occurrence of peri-implant diseases.
Rebecca Mayall has completed her DDS in 2011 from the University of Tennessee, Health Science Center College of Dentistry in Memphis, Tennessee. After completing her degree, she divided her time between private practice and working as a clinical instructor at the College of Dentistry. In 2013, she was hired as an Assistant Professor in the Prosthodontics Department where she currently lectures in the preclinical courses and instructs in the clinic.