Assessment Of The Gastropanel Test As A Non-invasive Diagnosis Of Atrophic Gastritis | 15942
Journal of Cancer Science & Therapy
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astric colonization by
increases the risk of atrophic gastritis and gastric cancer. Serum levels of
pepsinogen I and gastrin-17 which are respectively biomarkers of corpus and antrum mucosal activity are well known
parameters of atrophic gastritis. We examined the diagnostic efficacy of GastroPanel serological kit (pepsinogen I& II, gastrin-17
IgG), in diagnosing and scoring atrophic gastritis. Dyspepsia patients undergoing gastroscopy with biopsy were
recruited prospectively on voluntary basis at the Yaounde Central and University Teaching Hospitals, from March to July 2011.
The degree of atrophy was classified according to levels of serum pepsinogen I &II, gastrin-17 and
IgG and compared
with histological profiles. 86 volunteers aged 21 to 83, mean ± C.I. (46.4±3.3) were enrolled. The prevalence of gastritis was
statistically similar between GastroPanel test and histology (89.5% versus 83.7%: p>0.20). However, the GastroPanel diagnosed
more atrophic gastritis than histology (17.4% versus 7.0%: p<0.01), especially at antrum of stomach with
For the scoring of atrophy, the accuracy (69.77%), sensitivity (85.70%) and specificity (88.60%) were calculated. The prevalence
of H. pylori-infection did not differ significantly between serological and histological methods (84.9% versus 81.4%, p>0.05).
These results suggest that diagnosis of atrophic gastritis and
infection obtained with an optional serological method,
GastroPanel is in strong agreement with biopsy findings, and thus can be a useful non-endoscopic assessment of stomach mucosal
atrophy in patients with dyspepsia.
Alonge Ivo Ebule has completed his M.Sc. in Medical Immunology at the age of 30 from University of Yaounde 1 in 2012 and a Bachelor of Medical Laboratory Sciences from the University of Buea in 2007. Since 2006, he has assumed a leadership role in gastric research. He is a consultant with the Ministry of Public Health and several non-governmental organizations. He has published 03 papers in gastric diseases and has participated actively in other research areas including immunopathology of malaria and onchocerciasis with the use of cytokines along the Sanaga valley of Cameroon.