alexa Assessment Of Toxicogenetic Activity Of Oleoresins Of Five Copaifera Species For Prediction Of Potential Human Risks
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

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9th Euro-Global Summit on Toxicology and Applied Pharmacology
June 22-24, 2017 Paris, France

Denise C Tavares, Ricardo A Furtado, Pollyanna F Oliveira, Juliana M Senedese, Saulo D Ozelin, Larissa D R Souza, Luis F Leandro, Wendel L Oliveira, Jonas J M Silva, Larissa C Oliveira, Herve L G Rogez, Sergio R Ambrosio, Rodrigo C S Veneziani and Jairo K Bastos
University of Franca, Brazil
University of São Paulo, Brazil
Federal University of Pará, Brazil
Posters & Accepted Abstracts: J Clin Toxicol
DOI: 10.4172/2161-0495-C1-025
The uses of Copaifera species in folk medicine are related to a wide variety of pharmacological properties. This paper reports the cytotoxic and genotoxic analysis of oleoresins of five Copaifera species: C. duckei, C. multijuga, C. paupera, C. pubiflora and C. reticulata. In vitro assays were performed using Chinese hamster lung fibroblasts (V79 cells). The clonogenic efficiency and cytokinesis-block micronucleus assays were employed for the cytotoxicity and genotoxicity assessment, respectively. The mouse bone marrow micronucleus test was used for in vivo studies. The HPLC-MS and CG/MS analysis of Copaifera oleoresins allowed the identification of the 10 acid diterpenes and 11 major volatile compounds. The results showed that the oleoresins were cytotoxic by the clonogenic efficiency assay. The IC50 values ranged from 9.8 to 60.8 μg/mL. However, no cytotoxic effect was observed in the in vivo studies. Additionally, the treatments with oleoresins did not significantly increase the frequency of micronuclei in both in vitro and in vivo mammalian cells. The oleoresins of five Copaifera species evaluated were not cytotoxic in vivo, as well as they were not genotoxic in both in vitro and in vivo test systems, under the experimental conditions used. Therefore, the oleoresins of the species Copaifera evaluated were considered safe for human use.

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