To explore relationships between the early-onset solid cancer and HLA-DRB1 allelic polymorphism and develop an efficient research
method for identifying early onset solid cancer-related genes. Patients with different solid cancers, including gastric, liver, and lung
cancers, were recruited as the cancer group. On the basis of their age at the time of the first surgery, 70 patients were divided into the
following 7 age groups with 5 males and 5 females in each group: < 50 years, 50?54 years, 55?59 years, 60?64 years, 65?69 years, 70?74
years, and 75?79 years. The 70 healthy subjects, who were also divided into 7 age groups as was the cancer group, were served as the
control group. The samples were typed using an HLA-DRB1 PCR-SSP typing kit. The mean age of patients and healthy subjects with and
without the alleles was calculated respectively. In the cancer group, the mean age of patients with HLA-DRB1*01 (52.5 years old) was
less than that of patients without this allele (62.1 years old). There was an interaction between the mean age of patients in both groups
(cancer and control) and the genes (positive and negative expression; p < 0.05). HLA-DRB1 alleles may be involved in the pathogenesis
of early-onset solid cancer. The inherent anti-cancer mechanisms may be a common pathway for different cancers and are associated
with the immune system and HLA.
Liu Hui is a Professor in Department of Clinical Immunology at Dalian Medical University.
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