alexa Association Between The Specific UGT1A1 Promoter Sequence Variant (c-3279T>G) And Unconjugated Neonatal Hyperbilirubinemia | 71145
ISSN: 2167-0889

Journal of Liver
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

CO-ORGANIZED EVENT: 5th World Congress on Hepatitis & Liver Diseases & 2nd International Conference on Pancreatic Cancer & Liver Diseases
August 10-12, 2017 London, UK

Rania Hosny Tomerak
Cairo University, Egypt
Posters & Accepted Abstracts: J Liver
DOI: 10.4172/2167-0889-C1-015
Abstract
Background: Neonatal hyperbilirubinemia is a common presentation, yet the diagnosis is not reached in many cases. We investigated the association between UGT1A1 promoter sequence variant (c-3279T>G) and unconjugated neonatal hyperbilirubinemia. Methods: 141 neonates  36 weeks gestation were recruited; 63 were included in the jaundice group and 78 age and gender matched neonates with bilirubin < 7 mg/dl were included in the non-jaundice (control) group. Inclusion criteria in the jaundice group were newborns having indirect hyperbilirubinemia necessitating treatment. Newborns presenting with sepsis, asphyxia, cephalohematoma, polycythemia, viral hepatitis and prior blood transfusion or exchange transfusion were excluded. Results: The frequency of occurrence of c.-3279T>G Allele was significantly higher in the jaundice group (49.2%) than in the non-jaundice group (25.6%). The homozygous state (p=0.001, OR=17.7 & CI 3.9–79.3) rather than the heterozygous state (P=0.3, OR=0.7 & CI=0.3-1.6) was associated with development of hyperbilirubinemia. Among the jaundice group, comparison between the three genotypes; homozygous mutation, heterozygous mutation and the normal allele, revealed that the former represented a major morbidity as reflected by the significantly higher mean peak total serum bilirubin (mean±SD: 33.7±8.2, 26.9±2.8 and 21± 2.7 respectively, p-value 0.0001), higher bilirubin/albumin ratio (p=0.000) and a longer duration of hospital stay (p=0.001). All the homozygous cases presented with an exchange level of bilirubin and 55% had bilirubin induced encephalopathy. Conclusion: Homozygous c.-3279T>G mutation represents an important risk factor for the development of neonatal jaundice and its presence is associated with high bilirubin levels.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version