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Introduction: The associations between periodontitis and Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD)
have been well established recently. However, the association between periodontitis and subclinical cardiac dysfunction is not
clear. In this study, our goal was to investigate the relationship between periodontitis and asymptomatic cardiac dysfunction by
1) basic dental test and 2) detailed cardiac assessment using echocardiography.
Methods: 85 T2DM patients without cardiovascular diseases histories were enrolled. Dental test and transthoracic
echocardiography were performed for the patient. Echocardiographic images were analyzed in detail with the following
parameters i) Left ventricular function evaluated by Simpson’s method derived ejection fraction (LVEF) and speckle tracking
derived global longitudinal strain (GLS), ii) diastolic function was assessed by tissue Doppler derived E’ and E/E’ ration. Dental
measurement parameter including1) tooth loss number (TL) and probing depth (PD).
Result: The mean age of the recruited participant are 59.9±9.1, 48.2% of them are male. Even though LVEF didn’t have significant
relationship with dental parameters, TL and PD sill had significant correlation with GLS (r=0.32, p<0.01 and r=0.36, p<0.01,
respectively). As to diastolic function, E’ and E/E’ also significantly associated with TL (r=-0.31, p<0.01 and r=0.32, p<0.01,
respectively) and PD (r=-0.27, p=0.1 and r=0.31, p<0.01, respectively). Furthermore, multivariate analysis demonstrated TL
and PD were the independent predictors of impaired GLS and E’.
Conclusion: This study detected an independent relationship between the severity of periodontitis and cardiac systolic and
diastolic dysfunction. These associations highlight the significance of further cardiac assessment and timely treatment for
diabetic patients with periodontitis in the absence of relevant cardiac symptoms.
Zhen Zhe is a PhD student with major in Cardiology. Her major research interest is cardiac imaging especially for patients with diabetes.