Maternal-fetal ABO incompatibility is associated with spontaneous abortion. Spontaneous abortion puts
subsequent pregnancies at risk of preterm birth. Our aim to study whether preterm birth is associated with maternal-newborn
ABO blood phenotype pairs.
is was a 1:2 retrospective case-control study. A total of 1,089 consecutive live singleton preterm births (<37
weeks) between August 2005 and May 2011 formed the case group. A total of 2,232 consecutive live singleton term births (≥37
weeks) between May 2008 and April 2009 formed the control group. We extracted data on the mothers and their newborns
from our neonatal electronic database and delivery room log book. We extracted ABO blood phenotypes using Cerner Lab
Information System Soft
ware. We used a Chi square test to study the association between preterm birth and 14 maternal-
newborn ABO pairs. We used maternal-newborn O-O pair as the reference group. We used a binary logistic regression analysis
to adjust for nine risk factors for preterm birth.
Preterm birth was associated with only maternal-newborn pairs B-A (odds ratio: 2.22, 95% confi
dence interval: 1.20-
4.11, P=0.01) and AB-B (odds ratio: 1.80, 95% confi
dence interval: 1.04-3.12, P=0.03). Both associations remained signifi
in the regression analysis.
Preterm birth is associated with two maternal-newborn ABO pairs, B-A and AB-B. Th
ndings require further
Dr. Sameer Al-Abdi has completed his neonatal-perinatal fellowship program at University of Calgary and University of Toronto,
Canada in 2005.
He is a consultant neonatologist at King Abdulaziz Hospital, Al-Ahsa area, Saudi Arabia. He is the director of electronic neona
tal database at King
Abdulaziz Hospital. He has published several papers in reputed journals and serving as an editorial board member of new peer-re
journal called Journal of Clinical Neonatology.
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