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|Patricia Hidalgo M and M Alvaro J Ruiz|
|San Ignacio-Pontificia Universidad Javeriana, Colombia|
|ScientificTracks Abstracts: J Hypertens|
|Statement of the Problem: Chronic hypoxia causes marked activation of the sympathetic nervous system and elicits systemic oxidative stress. Time of oxygen desaturation during sleep might be a risk factor for HBP and even more at higher altitudes. The purpose of this study was to describe whether the percentage of time of oxygen desaturation during a sleep study was associated with the presence of HBP or with higher AHI. Methodology & Theoretical Orientation: We performed a descriptive study among 648 patients attending the sleep lab. Sleep studies were interpreted according to the AASM parameters and the percentage of time of oxygen saturation below 90(TS90), 80(TS80) and 70(TS70) were calculated. The presence of HBP was documented by either by patient report, recorded medication or direct measurement of blood pressure levels at the beginning and at the end of the sleep study. Findings: HBP was associated with higher AHI (95% confidence interval [95% CI]: 25.9(23.40, 28.55) compared to no HBP (95% confidence interval [95% CI]: 15.9(13.97, 17.98), P-value <0.0001. Being male was associated with higher AHI. TS90 were higher in patients with HBP: 58.4(95%CI =52.64, 64.29) compared to those without HBP: 40.2(95% CI= 36.52, 44.05), P-value <0.0001. The effect estimate attenuated when TS below 80 or 70 was taken into account but remained significant (P-value = 0.0012). Conclusion & Significance: Low levels of oxygen saturation during sleep were associated with higher AHIs. Additional adjustment for lower oxygen saturation levels reduced the effect size of the association but remained significant. Further studies are needed to replicate these findings and to examine mechanisms underlying the observed association and the longterm consequences in HBP development and treatment.|
Alvaro J Ruiz and Patricia Hidalgo have their expertise in Internal Medicine, Clinical Epidemiology and Sleep Disorders at high altitudes. They have built their way of focusing after years of experience in medical practice, research and teaching both in hospital and education institutions. They are research seed leaders and have population based published papers and health guidelines.
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