alexa Asthma, Allergy And Polymorphisms In Vitamin D Pathway: A Cross Section Study
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

8th European Immunology Conference
June 29-July 01, 2017 Madrid, Spain

Alana Alcantara Galvao, Emília Maria M de Andrade Belitardo, Flavia de Araujo Sena, Juliana Mendonca dos Santos, Ryan dos Santos Costa, Camila Alexandrina Viana de Figueiredo, Maurício Lima Barreto and Neuza Maria Alcantara Neves
Federal University of Bahia (UFBA), Brazil
Gonçalo Moniz Institute - FIOCRUZ Bahia, Brazil
Posters & Accepted Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899-C1-037
Introduction: Vitamin D presents a highlighted immune system activity. Its deficiency or insufficiency has been associated with low asthma control. Also, genetic determinants on the vitamin D pathway have been associated with asthma. In this study, we investigated associations between vitamin D serum levels with atopy and asthma, as well as polymorphism genes of the vitamin D pathway. Methods: 25 (OH) vitamin D quantified from 970 of 11-17 years old Brazilians by ELISA. Asthma diagnosis was obtained by ISAAC, Phase III questionnaires. Specific IgE detection to allergens was performed by ImmunoCAP; DNA was extracted and genotyped using 2.5 Human Omni Biochip from Illumina. Statistical analyses were performed using PLINK 1.9 and SPSS 22.1 programs. Results: The prevalence of vitamin D insufficiency was 64% in 76 asthmatic and 62.5% in 446 atopic individuals; however there was no significant association between vitamin D and this outcomes. Negative correlation was found between vitamin D and specific IgE levels to Dermatophagoides pteronyssinus on atopic subjects (r=-0.11, p=0.04). Genetic variants in CYP2R1 gene, rs7935792 (C allele) (Beta 1.66; 95% CI 0.20-3.11) and rs7129781 (C allele) (Beta 1.55; 95% CI 0.07-2.96), were associated with vitamin D serum levels. In addition, the same variants had suggestive protection on asthma, but it was not significant (OR 0.74; 95% CI 0.39; 1.39; OR 0.73; 95% CI 0.38; 1.37, respectively). VDR variants rs7965397 (G allele) was positively associated with atopy (OR 1.43; 95% CI, 1.07-1.92); rs4328262 (G allele) (OR 1.44; 95% CI 1.09-1.90) and asthma rs2408876 (C allele) (OR 2.31; 95% CI; 1.18-4.53); rs2238317 (T allele) (OR 2.19; 95% CI 1.02-4.72). Conclusions: Vitamin D can modulate the immune system and reduce allergic biomarkers. Genetic variants in CYP2R1 regulated vitamin D levels, and must prevent asthma symptoms. Genetic variants in VDR were associated with asthma and atopy susceptibility may be by modifying VDR expression.

Alana Alcântara Galvão has completed her graduation in Pharmacy, Master’s in interactive processes of the organs and systems by the Federal University of Bahia (UFBA) and currently is a PhD student of Immunology at UFBA. She is actually working in Laboratory of Allergy and Acarology (LAA). Her research covers immunoepidemiology, immunomodulation and immunogenetics. She collaborated with projects like: Research on the prevalence of respiratory allergies and their risk factors in children from rural areas in the city of São Francisco do Conde, Bahia (2010); An asthma cohort in children and adolescents of the city of Salvador - Bahia, SCAALA (Social Change in Asthma and Allergy in Latin America) (2012); Immunogenetic study on possible associations between Vitamin D, atopy and asthma in children and adolescents of Salvador, Bahia (2014). The objective of her study is to identify the association of vitamin D with asthma and atopy, highlighting genetic variants in vitamin D pathway.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version