Asthma, Allergy And Polymorphisms In Vitamin D Pathway: A Cross Section Study | 67450
Journal of Clinical & Cellular Immunology
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Asthma, allergy and polymorphisms in vitamin D pathway: A cross section study
8th European Immunology Conference
Alana Alcantara Galvao, Emília Maria M de Andrade Belitardo, Flavia de Araujo Sena, Juliana Mendonca dos Santos, Ryan dos Santos Costa, Camila
Alexandrina Viana de Figueiredo, Maurício Lima Barreto and Neuza Maria Alcantara Neves
Federal University of Bahia (UFBA), Brazil
Gonçalo Moniz Institute - FIOCRUZ Bahia, Brazil
Introduction: Vitamin D presents a highlighted immune system activity. Its deficiency or insufficiency has been associated with low
asthma control. Also, genetic determinants on the vitamin D pathway have been associated with asthma. In this study, we investigated
associations between vitamin D serum levels with atopy and asthma, as well as polymorphism genes of the vitamin D pathway.
Methods: 25 (OH) vitamin D quantified from 970 of 11-17 years old Brazilians by ELISA. Asthma diagnosis was obtained by ISAAC,
Phase III questionnaires. Specific IgE detection to allergens was performed by ImmunoCAP; DNA was extracted and genotyped
using 2.5 Human Omni Biochip from Illumina. Statistical analyses were performed using PLINK 1.9 and SPSS 22.1 programs.
Results: The prevalence of vitamin D insufficiency was 64% in 76 asthmatic and 62.5% in 446 atopic individuals; however there was
no significant association between vitamin D and this outcomes. Negative correlation was found between vitamin D and specific IgE
levels to Dermatophagoides pteronyssinus on atopic subjects (r=-0.11, p=0.04). Genetic variants in CYP2R1 gene, rs7935792 (C allele)
(Beta 1.66; 95% CI 0.20-3.11) and rs7129781 (C allele) (Beta 1.55; 95% CI 0.07-2.96), were associated with vitamin D serum levels.
In addition, the same variants had suggestive protection on asthma, but it was not significant (OR 0.74; 95% CI 0.39; 1.39; OR 0.73;
95% CI 0.38; 1.37, respectively). VDR variants rs7965397 (G allele) was positively associated with atopy (OR 1.43; 95% CI, 1.07-1.92);
rs4328262 (G allele) (OR 1.44; 95% CI 1.09-1.90) and asthma rs2408876 (C allele) (OR 2.31; 95% CI; 1.18-4.53); rs2238317 (T allele)
(OR 2.19; 95% CI 1.02-4.72).
Conclusions: Vitamin D can modulate the immune system and reduce allergic biomarkers. Genetic variants in CYP2R1 regulated
vitamin D levels, and must prevent asthma symptoms. Genetic variants in VDR were associated with asthma and atopy susceptibility
may be by modifying VDR expression.
Alana Alcântara Galvão has completed her graduation in Pharmacy, Master’s in interactive processes of the organs and systems by the Federal University of Bahia (UFBA) and currently is a PhD student of Immunology at UFBA. She is actually working in Laboratory of Allergy and Acarology (LAA). Her research covers immunoepidemiology, immunomodulation and immunogenetics. She collaborated with projects like: Research on the prevalence of respiratory allergies and their risk factors in children from rural areas in the city of São Francisco do Conde, Bahia (2010); An asthma cohort in children and adolescents of the city of Salvador - Bahia, SCAALA (Social Change in Asthma and Allergy in Latin America) (2012); Immunogenetic study on possible associations between Vitamin D, atopy and asthma in children and adolescents of Salvador, Bahia (2014). The objective of her study is to identify the association of vitamin D with asthma and atopy, highlighting genetic variants in vitamin D pathway.