alexa ATF4 Gene Network And ROS Mediate Cellular Response To The Anticancer PAD Inhibitor YW3-56
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

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4th World Congress on Cancer Science & Therapy
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Yanming Wang , Xiangyun Amy Chen, Jing Hu, Gong Chen, Craig Thomas, B Frank Pugh and Shu Wang
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.033
Abstract
We previously reported that a pan-PAD inhibitor YW3-56 activates p53 target genes to inhibit cancer growth. However, the broad anticancer efficacy and drug mechanisms of YW3-56 remained largely elusive. Here, gene expression analyses found that ATF4 target genes involved in ER stress response and oxidative stress response were activated by YW3- 56. Depletion of ATF4 greatly attenuated YW3-56 mediated activation of the mTORC1 regulatory genes, SESN2 and DDIT4. Using the ChIP-exo method, high-resolution genomic binding sites of ATF4 and CEBPB were generated prior to and after YW3-56 treatment. Moreover, YW3-56 increases cellular ROS levels to facilitate ATF4 target gene activation and cancer cell killing. YW3-56 mediated cell death features mitochondria depletion and autophagy perturbation. At last, YW3-56 treatment effectively inhibits the growth of triple negative breast cancer xenograft tumors in nude mice. Taken together, we unveiled the anticancer mechanisms and therapeutic potentials of the pan-PAD inhibitor YW3-56.
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