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Atrigel Drug Delivery System ? An Approach For Sustained Effect | 7576
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
Open Access

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2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

Sravani Yarlagadda
Accepted Abstracts: Pharmaceut Reg Affairs
DOI: 10.4172/2167-7689.S1.008
Abstract
The Parenteral administration route is the most effective and common form of delivery for active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. Though parenteral administration of drug is often critical and associated with problems such as limited number of acceptable excipients, stringent requirements of aseptic production process, safety issues, and patient noncompliance, still this route maintains its value due to special advantages like quicker onset of action in case of emergency, target the drug quickly to desired site of action, prevention of first pass metabolism etc. The application of advanced drug delivery technology to parenteral administration led to development of liposomes, nanosuspensions, solid implants etc. to overcome limitations of conventional parenteral delivery.There are currently two major types of biodegradable polymer systems for parenteral drug delivery. Solid implants can be made from biodegradable polymers using well-controlled manufacturing processes, such as extrusion, injection molding, and compression molding. These devices normally have very reproducible release profiles. However, because of their size, they require surgical implantation or the use of large trochars to administer the product. These methods of administration often limit the product's market potential due to patient and physician acceptance issues. Delivery systems consisting of microparticles, on the other hand, can be injected into the body using conventional needles and syringes. Thus, they have been the most widely accepted biodegradable polymer system for parenteral uses. However, the manufacturing processes for microparticles are often complex and difficult to control. As a result, there are often questions involving costs and batch-to-batch product uniformity. The rationale for developing the ATRIGEL? technology was the need for a delivery system that had the simplicity and reliability of solid implant devices, but the convenience and ease of administration of microparticles.The Atrigel? system is a proven sustained-release drug delivery platform that delivers therapeutic levelsof a wide spectrum of drugs over a few days toseveral months with a single injection.The Atrigel? drug delivery system consists of biodegradable polymers dissolved in biocompatible carriers.When the liquid product is injected into the subcutaneous space through a small gauge needle or placed into accessible tissue sites through a cannula, water in the tissue fluids causes the polymer to precipitate and trap the drug in a solid implant. The drug encapsulated within the implant is then released in a controlled manner as the polymer matrix biodegrades with time.Atrigel can deliver a wide range of therapeutics including small molecules, peptides, proteins, vaccines, natural products, etc.
Biography
I have completed by B pharmacy from Sri Venkateswara College of Pharmacy and pursuing my M pharmacy (pharmaceutics) in Vignan Institute of Pharmaceutical Sciences. I have presented oral and poster presentations in national level seminars.
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