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Augmentation In LDL-cholesterol With Aging Leads To Oxidative Stress And Disturb Sphingolipid Metabolism | 43856
ISSN: 2153-0769

Metabolomics:Open Access
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Augmentation in LDL-cholesterol with aging leads to oxidative stress and disturb sphingolipid metabolism

5th International Conference and Exhibition on Metabolomics

Miso Kang, Minjoo Kim, Minkyung Kim, Hye Jin Yoo and Jong Ho Lee

Yonsei University, Korea

Posters & Accepted Abstracts: Metabolomics

DOI: 10.4172/2153-0769.C1.032

We investigated that increase in circulating levels of low-density lipoprotein cholesterol (LDL-cholesterol) by aging may cause alterations in plasma metabolites. Among 596 healthy, nondiabetic subjects (aged 30-65 years), 390 individuals had normal levels of LDL-cholesterol at baseline, 53 subjects were in high levels of fasting LDL-cholesterol after 3 years. The 337 individuals, who retained normal LDL-cholesterol levels after 3-year follow-up, were matched for age, gender, BMI, and fasting LDL-cholesterol, and the matched group was included as the control group (n = 75). At the 3-year follow-up, total-cholesterol, LDL-cholesterol, oxidized LDL (ox-LDL), lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, and urinary 8-epi-prostaglandin F2a were increased in the high-LDL group than those of the control group. The high-LDL group also showed significant decreases of sphingomyelin (SM) (d18:0/16:1) and phosphatidylcholine (PC) (18:0/20:4), associated with an increases of LDL-cholesterol, and significant increases of palmitic amide and lactosylceramide. Mean changes of SM (d18:0/16:1), C17 sphinganine, PC (18:0/20:4), and lysoPCs (C16:1, C16:0, C17:0, C18:1, C18:0, C20:4, C20:3, and C22:6) were statistically different between the control and the high-LDL groups. Overall, the changes of ox-LDL positively correlated with changes of LDL-cholesterol, Lp-PLA2 activity, palmitic amide, oleamide, lysoPCs, and C17 sphinganine, and negatively correlated with changes of SM (d18:0/16:1). Increase in LDL-cholesterol induced by aging is associated with increased oxidative stress and disturbed sphingolipid metabolism.

Miso Kang is a PhD student working at Yonsei University Clinical Nutrigenetics/Nutrigenomics Laboratory with Jong Ho Lee. She consulted on a variety of projects, involving qualitative and quantitative analysis to achieve acquisitions, restructurings, and starategic realignments with her team. She has published 1 paper in reputed journal.

Email: [email protected]