alexa Auto-regulation Of Cerebral Blood Flow And Elder Diabetes-related Alzheimers Disease
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

10th International Conference on Neuroscience and Neurochemistry and 6th International Conference on Vascular Dementia
February 27-March 01, 2017

Fan Fan
University of Mississippi Medical Center, USA
ScientificTracks Abstracts: J Neurol Neurophysiol
DOI: 10.4172/2155-9562.C1.043
Abstract
Alzheimer's disease (AD) and diabetes (DM) are two of the most common diseases of aging. More than five million Americans have AD, and 29 million Americans have DM. The cumulative incidence of AD is 12.5% and DM is 26.9% among people 65 and older in the US. Evidence suggests that DM is linked with the development of AD, and these diseases are associated with cerebral vascular dysfunction. However, the mechanisms involved have not been fully elucidated. The present studies examine whether the myogenic response of middle cerebral artery (MCA) and auto-regulation of cerebral blood flow (CBF) are impaired in the T2DN rat, a type 2 diabetic (T2DM) strain, and whether these impairments contribute to the development of dementia and AD. Our data indicate that the myogenic response of MCA and auto-regulation of CBF are impaired in T2DN rats with aging. This cerebral vascular dysfunction is in association with blood-brain barrier (BBB) leakage, neurodegeneration and learning and memory dysfunction. Our results also demonstrate that the neurodegeneration in elderly T2DN rats is associated with elevated expression of beta-amyloid (Aβ) and Tau in the brain, suggesting these diabetic rats expresses the characteristic biomarkers of AD. The expression of GFAP and IL-1β is elevated in aged T2DN rats indicating that glial activation and inflammation may link aging, diabetes and cognitive deficits in this model. In summary, our studies suggest that the impaired auto-regulation of CBF plays an important role for the development of cognitive dysfunction and AD, and present information critical to the development of new treatments to prevent elder and DMrelated dementia including AD.
Biography

Fan Fan is an Assistant Professor at University of Mississippi Medical Center, USA. Her research focuses on the genetic basis of the impaired myogenic response and auto-regulation of cerebral and renal blood flow and end organ damage in aging, hypertension and diabetes. She has published more than 30 papers. She currently serves as a Peer Reviewer for the American Heart and Alzheimer’s Associations, and is an Editorial Board Member and reviewer for several journals. Her work is funded by the National Institutes of Health (NIH) and the American Heart Association (AHA) to study roles of Add3 (NIH/NIA, NIH/NIDDK), CYP4A1 and 20-HETE (NIH/NIGMS, AHA) on aging and hypertension-related renal and cerebral vascular and dementia.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version