Journal of Vaccines & Vaccination

Bacterial ghost: Novel approach of vaccine delivery in aquaculture

International Conference & Exhibition on Vaccines & Vaccination

22-24 Nov 2011 Philadelphia Airport Marriott, USA

Sontakke U.B, Muneendra Kumar, S.K. Asraf Houssain, Sagar Jadhav, Patil C.S and Harjit Kaur

Scientific Tracks Abstracts: J Vaccines Vaccin

Abstract:

Th e purpose of vaccination is to enhance the immune system of an animal and recognize pathogenic agent to reduce the severity of a disease. Oral vaccination technique like; killed pathogen, bacterial ghost, subunit, attenuated vaccine are in use at present. Among which, heat killed and attenuated vaccine oft en results altering the antigenic site or epitope. Th ough, the use of subunit vaccine is projected as substitute fo r the heat killed and attenuated vaccine and can be easily produced by expression of gene of interest in a host cell but its use in aquaculture is less it is mainly due to its poor immunogenic property and animals are not exposure to natural state of pathogenic part. Hence new approaches or methods should be developed to improve the vaccination in fi sh. Th e bacterial ghost system is one such vaccine. Bacterial ghost (BGs) is mainly derived from gram negative bacteria. BGs provide intrinsic adjuvant property to the animal and delivery system for drugs and DN A vaccine etc. Bacterial ghost can be produced by expression of gene E (bacteriophage phiX174) in a target cell. BG of Edwardsiella tarda admistration to olive fl ounder ( Paralichthys olivaceus ) has found to be eff ective in preventing or protecting the fi sh from edwardsiellosis. Th e admistarion of BG via oral, immunization and immersion are eff ective in reducing the diseases in fi sh. Hence Bacterial ghost is a novel vaccine candidate and a delivery system. It also provides natural adjuvant property, easy manufacturing, low production costs, and excellent safety profi le. Hence, it is a promising technology for the development of more effi cient vaccine in aquaculture practices

Biography :

Dr.Sontakke U. B. has completed his B.V.Sc & A.H. with distinction from Maharashtra Animal and Fishery University Nagpur and doing post-graduation studies from National Dairy Research Institute, Karnal, Haryana (India).He has consistent academic record with distinction. He has been awarded as Junior Research Fellow by Indian Council of Agricultural Research. He is member of veterinary Council of India (VCI) and member of Animal Nutrition Society of India (ANSI). He has published two papers and fi ve abstracts in International conferences and has been invited for oral presentation