Journal of Bacteriology & Parasitology

Bacterial infections and emerging resistance in renal transplant recipients

3^rd International Congress on Bacteriology and Infectious Diseases

August 04-06, 2015 Valencia, Spain

Inam Danish Khan

Posters-Accepted Abstracts: J Bacteriol Parasitol

Abstract:

Background: Renal transplantation is frequently complicated by bacterial infections in the scenario of immunosuppression,
altered metabolism and interventions resulting in prolonged morbidity. Subdued clinical presentation, antimicrobial resistance
and toxicity tend to jeopardize the outcome of transplantation. This study conducted at tertiary care apex transplant centre
highlights colonization, clinical infection and antimicrobial resistance patterns in Renal Transplant Recipients (RTR) in
comparison with nephrology ward in-patients (NIP).
Methods: Infection and antimicrobial resistance patterns in 65 RTR in comparison with 80 NIP were studied. Clinico
demographic and transplant parameters were noted. Infection screening in the post-transplant period along with antimicrobial
susceptibility were used to analyze data in a post-transplant time frame.
Results: Culture positivity timeline was dominated by post-surgical infections in the first week post- transplant. Urinary
infections followed by blood stream infections were noted. Infection profile included simultaneous poly microbial, prolonged
and widespread infections. Multiresistant organisms producing beta lactamases and extended spectrum beta lactamases were
isolated.
Conclusion: Transplant recipients remain prone to bacterial infections with multiresistant organisms which may persist due
to immunosuppression, altered metabolism and toxicity and further contribute to nosocomial hazard. Infection control may
be strengthened at avoidance of donor derived infections, surgical complications, epidemiologic exposures, antimicrobial
prophylaxis and anti-infection engineering. Antimicrobial stewardship, outbreak and epidemic preparedness should be
ensured.