Nasim Taghavi
Shahid Beheshti, University of Medical Sciences. Iran
Posters & Accepted Abstracts: J Cancer Sci Ther
Lichen planus is a common immune-mediated disease that is associated with an increased risk of malignant transformation in the oral cavity. Synchronous up-regulation of COX-2 and down regulation of Bcl-2 have been demonstrated in some malignancies. The aim of this study was to assess the correlation between COX-2 and Bcl-2 expression and their role in dysplastic changes of oral lichen planus (OLP). This study was performed on 47 paraffin blocks with the diagnosis of OLP.Immunohistochemical staining was performed using antibodies against COX-2 and Bcl-2. Spearman�s rank correlation coefficient and Mann-Whitney test were used for data analysis.Data analysis showed significant correlation between the intensity of sub-epithelial Inflammation and the severity of basal cell layer degeneration (P=0.048). Significant up regulation of Bcl-2 and COX-2 was detected in sub-epithelial inflammatory infiltration (P<0.001, P=0,003). The amount and intensity of Bcl-2 and COX-2 expression were significantly correlated in subepithelial lymphocytic infiltration (P=0.013, P=0.019). In conclusion our findings indicated the effective role of Bcl-2 expression in decreasing apoptosis in the inflammatory infiltrate unlike the epithelium. The significant correlation of the intensity of Bcl-2 expression in the epithelium and the sub-epithelial inflammatory infiltrate with COX-2 expression and also the correlation of the intensity of inflammation with the severity of basal layer hydropic degeneration may imply that these two markers can induce malignant transformation in the affected epithelium in an indirect manner by the continuation of inflammation and activation of carcinogenic mechanisms. Key Words: Oral lichen planus , COX-2 , Bcl-2.
Email: nasim.taghavi@yahoo.com
Cancer Science & Therapy received 3968 citations as per Google Scholar report
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